1.0 MIOSHA Laboratory Standard
OSHA
issued the Laboratory Standard for employees working in laboratories (including
academic laboratories). The term "laboratory" is defined as "a
facility where the laboratory use of hazardous chemicals occurs”. It is a
workplace where relatively small quantities of hazardous chemicals are used on
a non production basis."
Most
employees are covered by another standard called the Hazard Communication
Standard. However, because of the dangers and uniqueness inherent in laboratory
work, employers are required to cover laboratory workers under the Laboratory
Standard.
The
Laboratory Standard is performance based. This means that OSHA provides the
basic outline requirements and then each employer writes a plan tailored to
their needs, all plans must contain standard operating procedures.
The
Hazard Communication Standard is a Federal Law, also called the Right to Know
Law, that states all who work with or around chemicals have the right to know
the following information about the chemicals that they may potentially be
exposed to. While the MIOSHA
Laboratory Standard supercedes the Hazard Communication Standard in chemical
laboratories the following tenants are defined in both.
Ø
The employee must be
informed on what is Present in the
work environment.
Ø
The employee must be
trained on the proper use and selection of Protective
equipment.
Ø
The employee must be
informed of what Effects the
chemical may have as a result of exposure to the chemical.
Ø
The employee must be
trained in methods to Detect the presence
of the chemical in their work environment.
In
general, the proper guidance for these topics to be trained on is found in the
material safety data sheet. A material
safety data sheet (MSDS) is a database on a chemical. Found in this data base are such things as substance
identification, physical data, fire and explosion data, toxicity, health
effects, reactivity, spill and leak procedures, and protective equipment. As this information is vital to proper handling
of chemicals it is mandatory that you read and understand each MSDS for each
chemical that you work with. Failure to
understand the hazards of the chemicals you work with will result in the
suspension of your laboratory work until the situation is corrected.
See appendix “Sample Material Safety Data Sheet” for an example.
2.0 Laboratory-Specific Standard Operating Procedures
Each
laboratory is responsible for developing laboratory-specific standard operating
procedures that include, at a minimum, 1) an inventory of chemicals to be used for
the procedure, 2) the hazards associated with their use, and 3) the measures to
be taken to prevent exposures or control of the hazards. See appendix “Sample Standard Operating
Procedure” for an example.
The
decision to purchase a chemical shall be a commitment to handle and use the
chemical properly from initial receipt to ultimate disposal.
Requests
for procurement of new chemicals shall be initiated by contacting the Chemical
Hygiene Officer. The Chemical Hygiene Officer shall determine
if the chemical to be purchased can be handled safely by the Department and
insure that training has been provided to the users of the new chemical. In the event that the chemical can not be
purchased through Chemistry Stores, located in the basement of the Chemical
Sciences and Engineering Building, the Chemical Hygiene Officer shall assist
with arrangements for safe procurement and receipt of the new chemical. All involved personnel prior to the procurement
of the chemical shall understand information on proper handling, storage and
disposal.
Chemical
Stores shall receive all chemicals. If
a chemical cannot be delivered to Chemical Stores personnel who receive these
chemical shipments shall be knowledgeable of the proper procedures for receipt,
see the Chemical Hygiene Officer for these procedures. It is important that chemicals are not
delivered to an office area where secretaries, visitors, etc do not have the
required training to be exposed to these chemicals. Chemical containers shall not be accepted without accompanying
labels, material safety data sheets and packaging in accordance with all
appropriate regulations. All chemical
shipments must be dated when received and again when opened. Upon receipt the chemical must be labeled as
presented in section 9.0.
All
chemicals, with the exception of radioactive chemicals, shall be stored
collectively in room 818 Dow Environmental Sciences and Engineering
Building. Chemicals used in
laboratories shall not exceed quantities needed for four to six weeks. The purpose of this is to minimize the risk
associated with chemicals in the laboratory and to maintain safe storage of
chemicals by equipping one storage room with the proper storage containment
systems. In the case of high purity chemicals or chemicals that are
packaged in very small quantities it may not be reasonable to transfer these to
a secondary container. In this
situation special provisions must be made and authorized by the CHO.
Ø
Received chemicals
shall be immediately moved to the designated storage area, room 818 Dow
Environmental Sciences and Engineering.
All glass containers shall be placed in carrying containers or remain in
the original shipping containers during transportation, for example the cardboard
box that the shipment was received in.
Ø
The storage area
shall be well illuminated, with all storage maintained below eye level. Large bottles shall be stored no more than
two feet from ground level. No
containers shall be placed on top of storage cabinets.
Ø
Chemicals shall be
segregated by hazard classification and compatibility in a well-identified
area, with local exhaust ventilation.
The Flynn Scientific, Inc, P.O. Box219, 131 Flynn St., Batavia, IL
60510, suggested shelf storage pattern, as presented in Appendix “Chemical
Storage and Classification System” shall be followed.
Ø
Mineral acids shall
be separated from flammable and combustible materials. Separation is defined by NFPA 49 as storage
within the same fire area but separated by as much space as practical or by
intervening storage from incompatible materials. Acid-resistant trays shall be placed under bottles of mineral
acids.
Ø
Acid-sensitive
materials such as cyanides and sulfides shall be separated from acids or
protected from contact with acids.
Ø
The storage area
shall not be used as a preparation or repackaging area.
Ø
The storage area in
Chemical Stores is typically accessible during normal working hours. The storage area is under the control of the
Manager of Chemical Stores. The storage
area in room 818 Dow Environmental Sciences and Engineering Building is
accessible during normal working hours.
The storage area in 818 is under the control of Chemical Hygiene
Officer. This area has limited access,
please make sure that you make arrangements to obtain your chemicals during
normal working hours. Do not forget
that entering the storage area requires the presence of two trained people and
is considered work of a hazardous nature.
Ø
When chemicals are
taken from the storage area, they shall be placed in a secondary container or
bucket.
Ø
Storage of chemicals
in laboratories at the lab bench or other work areas shall be limited to those
amounts necessary for ongoing research or teaching activities. The amount of chemicals at lab benches shall
be as small as practical. Chemicals in the workplace shall not be exposed to
excessive sunlight or heat.
Ø
Stored chemicals
shall be examined at least annually, by the person in charge of the laboratory
or storeroom, for replacement/deterioration/container integrity. The inspection should determine whether any
corrosion, deterioration, or damage has occurred to the storage facility as a
result of leaking chemicals. Unneeded items shall be properly discarded or
returned to Chemical Stores, if they will
accept them.
Each laboratory employee with the training, education and resources provided by supervision shall develop and implement work habits consistent with this CHP to minimize personal and coworker exposure to the chemicals in the laboratory. Based on the realization that all chemicals inherently present hazards in certain conditions, exposure to all chemicals shall be minimized.
General precautions that shall be followed for the handling and use of all chemicals are:
Ø
Skin contact with all
chemicals shall be avoided.
Ø
All employees shall
wash all areas of exposed skin prior to leaving the laboratory.
Ø
Mouth suction for
pipeting or starting a siphon is prohibited.
Ø
Eating, drinking,
smoking, gum chewing, or application of cosmetics in areas where laboratory
chemicals are present shall not be permitted.
These areas have been posted. Hands
shall be thoroughly washed prior to performing these activities.
Ø
Storage, handling and
consumption of food or beverages shall not occur in chemical storage areas, laboratories, or refrigerators, nor shall any glassware or utensils also used for laboratory operations be used
in the handling of food or beverages.
Ø
Any chemical mixture
shall be assumed to be as toxic as its most toxic component. For example EPA says that benzene in water
can be safe to drink at concentrations below 1.0 ppb, but if we know benzene is
in the water, we will give that sample the safety rating associated with
benzene.
Ø
Substances of unknown
toxicity shall be assumed to be toxic.
Ø
Laboratory employees
shall be familiar with the symptoms of exposure for the chemicals with which
they work and the precautions necessary to prevent exposure. This is accomplished by understanding the
information found in the material safety data sheet/standard operating
procedure for the chemical/process that you are working with.
Ø
In all cases of
chemical exposure the Permissible Exposure Limits (PELs) of MIOSHA shall not be
exceeded.
Ø
Specific precautions
based on the toxicological characteristics of individual chemicals shall be
implemented as deemed necessary by the Chemical Hygiene Officer (see 8.2). These special precautions are listed in
Section 9.0.
6.0 Laboratory Equipment and Glassware
Each employee and student shall keep the work area clean and uncluttered. All chemicals and equipment shall be properly labeled in accordance with Section 9.0. At the completion of each workday or operation, the work area shall be thoroughly cleaned and all equipment properly cleaned and stored.
In addition, the following procedures shall apply to the use of laboratory equipment:
Ø
All laboratory
equipment shall be used only for its intended purpose. For example do not use a
scoopula as a screwdriver or a beaker as a hammer.
Ø
All glassware will be
handled and stored with care to minimize breakage; all broken glassware will be
immediately disposed of in a broken glass container, see Appendix “Glassware
Disposal”.
Ø
All evacuated or
pressurized glass apparatuses shall be shielded to contain chemicals and glass
fragments should implosion or explosion occur.
If performing experiments at elevated pressure prior approval must be
given, see Prior Approval of Laboratory Activities section 18.0.
Ø
All laboratory
equipment shall be inspected on a periodic basis as specified and replaced or
repaired as necessary.
7.0
Personal Protective Equipment
Personal protective equipment (PPE) assessments are
required for every workspace. These are to be performed by the laboratory
supervisor (assistance will be provided by the Safety Officer and CHO as
requested). Upon the determination that
PPE is required for a workspace it will be the area supervisor’s responsibility
to enforce and train on the use of the indicated PPE for that work area. Training shall include the selection, use,
decontamination of, and deterioration of PPE.
The Safety Officer will train supervisors and assistance will be
provided by the CHO when chemical hazards are present. After the initial assessment is made the
area supervisor must notify the Safety Officer when work functions change in
that work area so that a new assessment can be made based on the new tasks
being performed in that work area.
Periodic inspections will be made of the work area by the Safety Officer
to ensure that the appropriate PPE is being used and in working order. It is the intent of this program to minimize
the amount of PPE required by maximizing engineering controls and
administrative controls. Wherever
possible employees will not be required to wear PPE other than safety eyewear,
routine hand protection, and laboratory coats.
When additional PPE is required, if possible, only the area supervisor
will be required to perform these tasks and use the indicated PPE. PPE assessments are kept on file by the
Safety Officer.
PPE
should never be worn in public areas.
Hazards must be contained in public areas.
Safety
glasses meeting ANSI Z87.1 are required for employees and visitors to the
laboratory and will be worn at all times when in the laboratory. Contact lenses are permitted in the
laboratory, if approved by the laboratory supervisor and safety glasses meeting
ANSI Z87 are worn over the contact lenses.
Note: Safety lenses in standard
eyeglasses are not ANSI approved. The
frames must also meet the appropriate standard. The glasses will have the Z87 stamped on them if they are
approved.
Ø
Chemical goggles
and/or a full-face shield shall be worn during chemical transfer and handling
operations as procedures dictate or when in a chemical storage area.
Ø
Sandals, sneakers and
bare feet are prohibited. Safety shoes,
per ANSI 47 are required where employees routinely lift objects over 65 lbs., see appendix “Personal Protective
Equipment Assessment Forms”.
Ø
Lab coats or aprons
are recommended for wear in the laboratory.
Laboratory coats shall be removed immediately upon discovery of
significant contamination.
Ø
Appropriate
chemical-resistant gloves based on the Table in Appendix “Glove Selection” and
the manufacture’s glove-specific chemical resistance data shall be worn at all
times when there may be skin contact with chemicals. Used gloves shall be inspected and washed prior to re-use. Damaged or deteriorated gloves will be
immediately replaced. Gloves shall be
washed prior to removal from the hands.
Disposable gloves shall not be reused.
Ø
Thermal-resistant
gloves shall be worn for operations involving the handling of cryogenic, heated
materials and exothermic reaction vessels.
Thermal-resistant gloves shall be non-asbestos and shall be replaced
when damaged or deteriorated.
Ø
All respirator use,
including paper dust masks, shall be approved by the Director of Occupational
Safety and Health Services. A separate
approval is required for each type of exposure.
Ø
Laboratory
supervision must ensure that each employee knows and follows the rules and
procedures established in this plan.
Ø
All employees shall
remain vigilant to unsafe practices and conditions in the laboratory and shall
immediately report such practices and/or conditions to the laboratory
supervisor. The supervisor must correct
unsafe practices and or conditions promptly.
Ø
Long hair and
loose-fitting clothing shall be confined close to the body to avoid being
caught in moving machine/equipment parts.
Ø
Use only those
chemicals appropriate for the ventilation system.
Ø
Avoid unnecessary
exposure to all chemicals by any route.
Ø
Do not intentionally
smell or taste any chemicals.
Ø
Encourage safe work
practices in coworkers by setting the proper example. Horseplay is strictly forbidden.
Ø
Seek information and
advice from knowledgeable persons, standards and codes about the hazards
present in the laboratory. Plan
operations, equipment and protective measures accordingly.
Ø
Inspect personal
protective equipment prior to use, and wear appropriate protective equipment as
procedures dictate and when necessary to avoid exposure. Personal protective equipment should not be
your primary safety guard; instead engineering controls should be your first line
of defense. If PPE becomes contaminated
the process should be halted and evaluated to determine means for preventing
this contamination. PPE is your last
line of defense.
All
containers in the laboratory shall be labeled, blank labels are provided by the
Department. This includes sample
containers and waste containers. The
label shall be informative, durable and include the information provided below. Directions
for assigning Hazard Statements can be found in appendix labeled Hazard
Statement. For information on storage
codes see appendix Chemical Storage and Classification System (Flynn Scientic
Inc.). For information on EPA Waste
Codes see appendix labeled Definition of Hazardous Waste.
Exemptions
for labeling requirements shall be made for chemical transfers from a labeled
container into a container that is intended only for the immediate use of the
employee who performed the transfer. At
no time shall the employee leave an unattended container that is unlabeled, not
even to use the restroom.
The
labeling program shall be periodically inspected by the Chemical Hygiene
Officer/laboratory steward/supervisor to ensure that labels have not been
defaced, removed or incomplete.
Required
Information:
Ø
Contents (full
chemical name – no abbreviations)
Ø
Date
Ø
Faculty or Staff Responsible
for the Chemical
Suggested Information:
Ø
Hazard Statement
Ø
Storage Code
Ø
EPA Waste Code
Ø
User
Date .
Owner (Faculty/Staff) .
Hazard Statement .
Storage Code .
EPA Waste Code .
User .
Misc. .
Information on Labeling: http://www.civil.mtu.edu/docu/CHP
Civil and Environmental Engineering, Michigan Technological
Uni.
All
laboratories shall have signs posted on or near the door to the laboratory
identifying the location of the MSDS(s) for that laboratory and designate it as
a Right to Know workplace. This sign
should also indicate the hazards present, names and phone numbers of the
responsible persons for this laboratory, see Appendix “Emergency Phone
Numbers”.
For
unattended operations see Appendix “Unattended Operations Notice”
11.0 Off Campus Transportation and Receipt of Chemicals,
Wastes, Samples or Testing Material for Treatability Studies.
Prior
to shipping or receiving any chemical, waste or sample the Chemical Hygiene
Officer should be notified. There are
extensive fines and possible imprisonment for violation of State and Federal
Laws associated with hazardous materials shipping. Fines typically range upward from five figures and are assessed
against the person offering the material for shipment and the employer. In order to be able to ship a package
containing chemicals from MTU an employee that is certified in Hazmat Shipping
must sign the Shipper Certification Form, see Appendix “Off-Campus Shipping of
Chemicals, Wastes, Samples, or Testing Materials”.
12.0 Waste
Generation, Storage and Disposal
Hazardous waste is defined in
appendix “Hazardous Waste”.
Ø
Waste Generation
Prior
to generating any waste, it is suggested that, whether thought to be hazardous
or not (except for office-type wastes), notification as to:
§
What the waste is
composed of
§
Quantity and
Frequency of Generation
§
Location of
Generation
§
Reason for Generating
the Waste
§
Proposed Disposal
Technique for the Waste
be
made to the Chemical Hygiene Officer and the Occupational Safety and Health
Services Office. It is unlawful to
treat any waste prior to disposal.
Ø
Waste Storage
The
following are some general guidelines and requirements for the handling,
accumulation, and storage of hazardous wastes that need to be followed.
§
All persons involved
with handling hazardous wastes must be trained in safe handling, proper
accumulation and storage procedures, emergency response procedures and spill
cleanup procedures.
§
Never mix waste
types; see appendix “Definition of Hazardous Waste for waste disposal
guidelines. This guideline does not
eliminate the need for collecting and sorting wastes by compatibility. Hazardous reactions can occur if
incompatible wastes are mixed. The
compatibility of wastes can be verified by reviewing the MSDS under the section
incompatibilities.
§
Keep incompatible
wastes separated by distance or a physical barrier (secondary container).
§
Hazardous waste must
be properly labeled and stored at the location where it has been
generated. In addition to the required
content label, a hazardous waste label must be affixed which includes the words
“Hazardous Waste”, the accumulation start date, and the EPA waste code. See appendix “Hazardous Waste Label” for
sample.
Ø
Waste Disposal
The
following is taken directly from the Michigan Technological University Safety Manual that can be found at
the follow web site address: http://www.sas.it.mtu.edu/fm/oshs/main.htm.
LABORATORY WASTE DISPOSAL
The
Resource Conservation and Recovery Act, RCRA, of 1976 and subsequent amendments
to the 1965 Solid Waste Disposal Act regulate the disposal of hazardous wastes.
RCRA defines hazardous wastes in two ways.
The first are those wastes that exhibit one or more of the
characteristics of ignitability, corrosivity, reactivity, and toxicity
according to specific definitions found in 40CFR 261 subpart C (see appendix
“Definition of Hazardous Waste”). The
second group of hazardous wastes are those that are specifically listed in
40CFR 261 subpart D. Michigan regulates
a number of wastes under its Hazardous Waste Management Act in addition to the
RCRA wastes. A complete list of
hazardous wastes regulated in Michigan can be obtained from Occupational Safety
and Health Services.
§
It is the
responsibility of every MTU employee, generating laboratory or other hazardous
wastes, to dispose of them in compliance with all federal, state, local, and
MTU regulations. Any MTU employee
generating laboratory or other wastes exhibiting one of the above
"characteristics" should contact the office of Occupational Safety
and Health Services for more information and assistance. Frequently, the MSDS for a material will
contain waste disposal and other information, which will help in determining
whether a waste might be regulated.
Hazardous waste must be collected in containers which are compatible
with the waste, do not leak, are kept tightly sealed except during filling, are
identified with an approved hazardous waste label, see appendix “Hazardous
Waste Label”, and are under the direct control of the laboratory
supervisor. Waste containers shall be
separated according to compatibility either by distance or secondary
containment.
§
To dispose of
hazardous waste, a collection form, see appendix “Hazardous Waste Collection
Form” must be completed and sent to Occupational Safety and Health Services. A
copy of the collection form should be affixed to the containers listed on the
form. After approval, Occupational
Safety will remove the waste to the collection site for disposal. Occupational Safety and Health Services does
not assume ownership of the wastes collected but provides a service to
coordinate and assist in disposal. Responsibility for disposal, sampling,
chemical analysis, and any other charges incurred as well as the accuracy of
the information supplied to OSHS remains with the department requesting
collection. Should the waste be found
unacceptable by the disposal facility for any reason, it may be returned to the
generator until suitable means for disposal can be arranged.
§
Occupational Safety
and Health Services should be and the CHO must be consulted as soon as possible
and, preferably, prior to the generation of potential hazardous wastes in order
to reduce disposal costs and ensures regulatory compliance.
Ø
Air sampling for
evaluating employee exposure to chemical substances shall be conducted if
deemed necessary based on Permissible Exposure Limits (PEL). Of particular concern are the chemicals
sighted in Michigan Occupational Safety and Health Rule 2301 and Group 1 Human
Carcinogen (EPA) see Appendix “Class 1 Carcinogens”.
Ø
Air sampling should
be initiated if there is no appropriate means for determining the presence or
release of a chemical in use in the work environment. This must be done prior to working with new chemicals. OSHS can assist in determining safe work
environments.
Ø
Upon addition of new
chemicals or changes in control procedures, additional air sampling may be
considered to determine the exposures.
Air sampling should be conducted if there is reason to believe that
exposure levels for regulated substances, that require sampling, routinely
exceed the action level, or in the absence of an action level, the PEL. Air sampling will be implemented when usage
of highly toxic substances outside of fume hoods or glove boxes exceeds three
times per week.
Ø
The results of air
sampling studies performed in the laboratory must be posted in the work area.
Ø
Air sampling must be
performed whenever workers exhibit symptoms of exposure.
Ø
Each laboratory
worker is directly responsible for the cleanliness of his or her workspace, and
jointly responsible for common areas of the laboratory. Laboratory management shall insist on the
maintenance of housekeeping standards.
Ø
The following
procedures apply to the housekeeping standards of the laboratory:
§
All spills on lab
benches or floors shall be immediately cleaned and properly disposed of, this applies only if the spill can be
cleaned up safely. The determination of what size of spill can be cleaned up safely
must be determined prior to the use of the chemical and should stated in the
SOP. In the event that it cannot be cleaned up safely the MTU
emergency response plan for chemical spills shall be implemented.
§
Lab benches shall be
kept clear of equipment and chemicals except those necessary for the work
currently being performed.
§
Work areas shall be
cleaned at the end of each operation or each day.
§
All apparatus(s)
shall be thoroughly cleaned and returned to storage upon completion of usage.
§
Floors, aisles,
exits, fire-extinguishing equipment, eyewashes, showers, electrical disconnects
and other emergency equipment shall remain unobstructed.
§
Labels shall face
front.
§
Chemical containers
shall be clean, properly labeled and returned to storage upon completion of
usage.
§
Chemical wastes will
be disposed of in accordance with the waste disposal plan.
15.0 Safety
and Emergency Equipment
Telephone numbers of emergency personnel, supervisors and other workers as deemed appropriate must be posted. Some emergency phone numbers are listed in Appendix “Emergency Phone Numbers”.
Ø
A fire extinguisher
shall only be used if the exit to the room is to the back of operator, and the
fire is no larger than a wastebasket or if the fire blocks the exit. Upon use of a fire extinguisher the fire
alarm shall be activated. Prior to the
procurement of new chemicals, the Chemical Hygiene Officer shall verify that
existing extinguishers and other emergency equipment are appropriate for such
chemicals. Employees who have not
received training in the use of portable fire extinguishers must follow the MTU
emergency evacuation procedure and are not required to use a fire extinguisher.
Ø
All employees who
might be exposed to chemical splashes shall be instructed in the location and
proper usage of emergency showers and eyewashes. The eyewash and emergency shower shall be inspected annually. Occupational Safety and Health Services Office shall perform
these inspections. The Safety Officer shall provide training to laboratory
supervisors. Supervisors shall provide
training to those they supervise.
Ø
Location signs for
safety and emergency equipment must be posted.
Ø
Intent
The
engineering controls installed in the laboratory are intended to minimize
employee exposure to chemical and physical hazards in the workplace. These controls must be maintained in proper
working order for this goal to be realized.
Ø
Modification
No
modification of engineering controls will occur unless testing indicates that
worker protection will continue to be adequate. Any modifications shall be made only an authorized person.
Ø
Improper Function
Improper
function of engineering controls must be reported to the Safety Officer,
Chemical Hygiene Officer or Occupational Safety and Health Services
immediately. The system shall be taken
out of service until proper repairs have been executed.
Ø
Usage
All
employees shall follow proper work practices when using the engineering
controls.
Local
Exhaust Ventilation (Elephant Trunks, Flexible Tubing)
The
following procedures shall apply to the use of local exhaust ventilation:
§
Openings of trunk or
tubing shall be placed as close as possible to sources of the air contaminant.
§
Trunk/tubing fans
shall operate when hoods are being used.
§
After using
trunk/tubing ventilation the fan should be operated for an additional period of
time sufficient to clear residual contaminants from the ductwork.
§
The ventilation
system shall be inspected annually by Occupational Safety and Health
Services. The duct velocity shall be
maintained at 3500 feet per minute, minimum.
§
Prior to a change in
chemicals or procedures, the Chemical Hygiene Officer or Occupational Safety
and Health Services shall determine the adequacy of the ventilation system.
Ø
Laboratory Hoods
The
laboratory hoods shall be utilized for all chemical procedures that might
result in release of hazardous chemical vapors or dust. As a general rule, the hood shall be used
for all chemical procedures involving substances that are appreciably volatile
and have a permissible exposure limit (PEL) less than 50 ppm. The Safety Officer shall provide training on
the use of hoods to supervisors.
Supervisors will train those they supervise.
The following work
practices shall apply to the use of hoods:
§
Confirm adequate hood
ventilation performance prior to opening chemical containers inside the
hood. An inward flow of air can be
confirmed by holding a piece of paper at the face of the hood and observing the
movement of the paper. Most hoods are
not locally controlled and are operated by facilities. Some hoods are on a timed schedule for being
turned on and off. Prior to use the
schedule should be checked to determine if this schedule is compatible with the
work to be performed in the hood. Hoods in Dow ESE are scheduled for
24-hour continuous operation.
§
Keep the sash of the
hood closed at all times except when adjustments within the hood are being
made. At these times, maintain the sash
height as low as possible. Some hoods have red arrows indicating
the maximum that the hoods sash can be opened and maintain the needed linear
velocity for the hood.
§
Storage of chemicals
and equipment inside the hood shall be kept to a minimum.
§
Minimize interference
with the inward flow of air into the hood.
This is accomplished by keeping items a distance of six inches from the
walls and sashes.
§
Leave the hood
operating when it is not in active use if hazardous chemicals are contained
inside the hood or if it is uncertain whether adequate general laboratory
ventilation will be maintained when the hood is non-operational.
§
The ventilation
system shall be inspected annually. The hood face velocity shall be maintained
between 75 and 150 feet per minute, the fume hoods in the Dow Building have
velocity monitors mounted on them and should be used to determine that adequate
velocity is being maintained during the use of the hood. Occupational Safety and Health Services
shall maintain a record of each inspection.
§
The hood shall not be
used as a means of disposal for volatile chemicals.
§
Prior to the
introduction of new chemicals, the Chemical Hygiene Officer will determine the
adequacy of hood ventilation systems if requested.
Ø
Glove Boxes and
Isolation Rooms
The
exhaust air from a glove box or isolation room will pass through scrubbers or
other treatment before released into the regular exhaust system, if the
chemicals or substances used require this action.
Ø
Cold Rooms and Warm
Rooms
If
procedures differ for these facilities from the standard procedures stated in
this Chemical Hygiene Plan, as determine by the project officer, a copy of the
SOP must be posted outside of the facility and a copy be submitted to the
Chemical Hygiene Officer/Safety Officer for approval.
Ø
Storage Cabinets
Storage
cabinets for flammable and hazardous chemicals will be ventilated as needed.
17.0 Employee
Information and Training
Ø
Hazard Information
All
employees will be apprised of the hazards presented by the chemicals in use in
the laboratory. Each employee shall
receive training at the time of initial assignment to the laboratory and prior
to assignments involving new exposure situations. This will be perform via implementation of this CHP/SOP and
validated by written testing.
Ø
Forms
The
form in appendix "New Employee Chemical Hygiene Orientation and Training
Checklist” shall be used for documenting training.
Ø
Training
§
The Chemical Hygiene
Officer shall provide new employee training covering the contents of this
Chemical Hygiene Plan. This training
must occur prior to starting work in any chemical laboratory and must be
refreshed annually. The following
topics are to be presented during this training:
Right-to-Know Law
Laboratory Specific Standard Operating Procedures
Chemical Procurement, Storage, Handling
PPE
Labeling
Waste Handling
Housekeeping
Engineering Controls
Permit System
Emergency Action Plan
§
Training supplied by
the Laboratory Supervisor shall include the following.
Introduction to operations where chemical and physical hazards are
present/types of hazards encountered.
Required work practices
PPE
Emergency procedures
Detection of chemical hazards
Location and training on SOP(s), MSDS(s), and CHP
Labeling system
Ø
Follow-up
Following
the training supplied by the Laboratory Supervisor the employee shall return to
the Chemical Hygiene Officer to:
Review work practices and procedures
Answer employee questions
Test
18.0 Prior
Approval of Laboratory Activities
Ø
Permit System
A
permit system shall be used for laboratory activities that present specific,
foreseeable hazards to the employees.
It is the responsibility of principal investigators, laboratory
stewards, and laboratory supervisors to submit a Laboratory Operations Permit
Request Form, see Appendix “Laboratory Operations Permit”, for these
activities. These activities include
sole occupancy of laboratory (when chemical hazards are present and when not in
verbal contact with another knowledgeable employee) and other hazardous
operations as outlined below are present.
§
Greater than 2.0
liters of organic solvent with a flash point of less than 20oC is
used,
§
More than 10 grams of
reactive metal is used in one experiment,
§
Reagents know to be
category I carcinogens are used (see Appendix “Class 1 Carcinogens” for a
list),
§
Materials that are
explosive are generated or used in the experiment,
§
Reaction has the
potential to become uncontrolled,
§
Poisonous gases are
used or produced,
§
Experiment is carried
out at elevated pressures,
§
Radioisotopes are
used in the experiment.
§
Unattended
operations,
§
Children in
laboratories, see Appendix “Children in Laboratories”.
Ø
Sole Occupancy
At
no time shall any work involving chemicals, mechanical equipment, or electrical
devices other than computers be performed in the laboratory when the only
knowledgeable person within hearing distance is the laboratory person
performing the work. A second person that
is knowledgeable of the work must be in verbal contact with the worker. Under unusual conditions, crosschecks,
periodic Public Safety checks, closed circuit television, or other measures may
be taken when permitted.
Ø
Hazardous Work
All
hazardous operations, as determined by the Laboratory Supervisor, Chemical
Hygiene Officer, or as defined as a hazardous operation above, are to be performed during a time when
at least two personnel are present at the laboratory. At no time shall a laboratory person, while working alone in the
laboratory, perform work that is considered hazardous.
Ø
Unattended Operations
When
laboratory operations are performed which will be unattended by laboratory
personnel (continuous operations, overnight reactions, etc.), the following
procedures will be employed:
§
The permit system
shall be utilized.
§
The laboratory
supervisor will review work procedures to ensure the safe completion of the
operation.
§
An appropriate sign
will be posted at all entrances to the laboratory. The sign must include the name of the operator, types of hazards
present, dates and times of operation, emergency procedures, and phone numbers
to contact in case of emergency or questions.
§
The overhead lights
in the laboratory will be left on.
§
Precautions shall be
made for the interruption of utility service during the unattended operation
(loss of water pressure, electricity, etc.).
§
The person
responsible for the operation will return to the laboratory at the conclusion
of the operation to assist in the dismantling of the apparatus and should be available
in case of emergency.
19.0 Medical
Consultations and Examinations
Ø
An opportunity to
receive medical attention is available to all employees who work with hazardous
chemicals in the laboratory. The
opportunity for medical attention will be made available to employees under the
following circumstances:
§
Whenever an employee
develops signs or symptoms associated with a hazardous chemical, to which the
employee may have been exposed in the laboratory,
§
Medical surveillance
programs will be established where exposure monitoring reveals an exposure
level above the action level for an MIOSHA regulated substance for which there
are exposure monitoring and medical surveillance requirements, and/or,
§
Whenever an event
takes place in the laboratory such as a spill, leak, explosion or other
occurrence resulting in the likelihood of a hazardous exposure the employee
will be provided an opportunity for medical consultation for the purpose of
determining the need for medical examination.
§
These medical
consultations and examinations shall be provided without cost to the employees,
without loss of pay and at a reasonable time and place.
§
These medical
consultations and examinations shall be administered by or under the direct
supervision of a licensed physician. Employees
seeking the opportunity of medical consultation should notify the Occupational
Safety and Health Services Office.
20.0 Chemical
Hygiene Responsibilities
Ø
Chief Executive Officer
C.
Robert Baillod has the ultimate responsibility for chemical hygiene throughout
the Department and with assistance of other program administrators, will
provide continued support for chemical hygiene.
Ø
Chemical Hygiene Officer
The Chemical Hygiene
Officer shall:
§
work with
administrators and other employees to develop and implement appropriate
chemical hygiene policies and practices,
§
monitor procurement
and use of chemicals in the lab, including determining that facilities and
training levels are adequate for the chemicals in use,
§
perform regular,
formal chemical hygiene and housekeeping inspections,
§
help project
directors develop precautions and adequate facilities,
§
maintain current
knowledge concerning the legal requirements of regulated substances in the
laboratory as provided by OSHS,
§
review and improve the
Chemical Hygiene Plan on an annual basis,
§
ensure that workers
know and follow the chemical hygiene rules,
§
determine the proper
level of personal protective equipment, ensure that such protective equipment
is available and in working order,
§
ensure that
appropriate training has been provided to employees,
§
monitor the waste
disposal program.
Ø
Laboratory Workers
The laboratory workers
are individually responsible for
§
planning and
conducting each laboratory operation in accordance with the Chemical Hygiene
Plan,
§
developing good
personal chemical hygiene habits.
§
developing
laboratory-specific standard operating procedures
21.0
Special Precautions (Working with Allergens, Embryotoxins, etc.)
When
laboratory procedures change to require the use of additional classifications
of chemicals (allergens, embryotoxins,
teratogens, carcinogens, etc.), additional special precautions shall be
implemented as deemed necessary by the Chemical Hygiene Officer and Laboratory
Supervisor. The permit system shall be
utilized for all special activities.
All questions regarding the use of the permit system should be addressed
to the Chemical Hygiene Officer.
Ø
Suitable gloves to
prevent hand contact shall be worn when exposed to allergens or substances of
unknown allergen activity. Allergens
are particularly hazardous compounds as they can cause the exposed person to
have a life threatening allergic reaction to the compound or enhance an
existing allergy.
Ø
Women of
child-bearing age maybe replaced with a male to handle embryotoxins and they will only work with them in a hood with confirmed satisfactory
performance and will use protective equipment to prevent skin contact as
prescribed by the supervisor and Chemical Hygiene Officer.
Ø
Embryotoxins will be
stored in adequately ventilated areas in unbreakable secondary containers.
Ø
The supervisor and
Chemical Hygiene Officer will be notified of spills and other exposure
incidents. A physician will be
consulted when appropriate.
Ø
The immediate supervisor
will conduct accident investigations with assistance from other personnel as
deemed necessary.
Ø
Accident reports need
to be completed within 24 hours by the supervisor and forwarded to OSHS.
Ø
A copy of each
incident and injury report shall be sent to the Department Chair.
Ø
Medical records for
employees exposed to hazardous chemicals and harmful physical agents will be
maintained by Portage Health Systems on behalf of MTU.
23.0 Emergency Action Plan for Spills, Releases,
and Accidents
If
it is determined that the nature and/or quantity of the spilled chemical will
affect anyone outside of the immediate area, the procedure for the evacuation
of the building must be initiated. That
procedure is as follows:
Ø
Sound the alarm at
the fire alarm box if there is a threat to the entire building otherwise only
evacuate the threatened area.
Ø
Dial 123 on the
nearest campus phone.
Ø
Identify yourself to
the operator and explain the nature of the incident. Be certain to specify If a fire or explosion hazard exists and/or
the need for emergency medical assistance.
Ø
If an employee is
injured notify Public Safety. Public
Safety will either call an ambulance for transporting the individual or Public
Safety will transport the individual.
At no time should an employee transport a sick or injured person other
than Public Safety. Individuals should
not transport themselves other than under the direction of Public Safety.
Ø
Request the
assistance of Occupational Safety and Health Services.
Ø
Restrict access to
the area to prevent bystanders, etc., from entering the building or area that
has been evacuated.
Ø
Proceed to the outer
entrance of the building or area and wait for the arrival of Public Safety and
Occupational Safety and Health
Services personnel.
Ø
Describe the nature
of the spill to emergency responders with emphasis on the hazard associated
with the material. Have MSDS ready for
reference.
Ø
The appropriate MSDS
shall accompany the victim of a chemical exposure sent to an emergency medical
facility or arrive shortly thereafter to help ensure proper treatment.
Ø
Emergency Action Plan for Fires or Responding to Fire Alarms
Ø
MTU Policy
Department Member Responsibilities for Emergencies
§
The signal to
evacuate the building in case of
emergency is the building fire alarm.
§
The evacuation must
be orderly. Walk to exits. It is the Departments member’s
responsibility to direct students to the safest exit.
§
Certain safety
precautions are necessary before actually departing, such as: turn off gas and
lights and close windows/doors, etc.
§
Building elevators
are not to be used for evacuation.
§
Elevators are for use
of rescue workers, police, and fire fighters.
The building custodian brings the elevators to the first floor. Personnel could become trapped in them by nature
of the emergency.
§
Personnel are not to
congregate in or around the building exits or doorways, once they are outside
the building or emergency area.
§
Personnel must be at
least 100 feet away from the building in case of falling debris and to enable
rescue or responding vehicles and personnel to get to the site of the
emergency.
§
Personnel may
re-enter the building only when the Public Safety Officer at the scene of the
emergency situation gives the “All Clear”.
The Public Safety Officer promptly informs building evacuees of the
reason for the evacuation.
§
Department heads must
make arrangements for safe evacuation of staff with mobility impairments. Faculty are responsible for making
arrangements for their student with such impairments.
§
Students and employees
who need assistance are to wait until the others
have evacuated so as not to cause delays at exit openings and stairs.
§
Persons in wheel chairs are
to be assisted to a designated safe refuge area (usually the landing of an
enclosed stairway) if evacuation is necessary from other than a ground level
floor. A designated person will direct
fire fighters to the location of anyone waiting for assistance in a safe refuge
area.
24.0
Annual Chemical Hygiene Plan Audit
The Chemical Hygiene Officer will conduct an audit of the Chemical Hygiene Plan each year. Results will be provided to the ranking official. The laboratory Supervisors are responsible for taking corrective action.
25.0
References and Recommended Reading
National
Research Council, Prudent Practices for Handling Hazardous Chemicals in
Laboratories, National Academy Press, Washington, D.C. 1981.
National
Research Council, Prudent Practices for Disposal of Chemicals from
Laboratories, National Academy
Press, Washington, D.C., 1983.
Freeman,
N.T., Introduction to Safety in the Chemical Laboratory, Academy Press, 1982.
Manufacturing
Chemists' Association, Inc., Guide For Safety In The Chemical Laboratory, D.
Van Nostrand Company, Inc., 1954.
Green,
Michael E., Safety in Working with Chemicals, MacMillan Publishing Co.,
Inc. 1978.
Pipitone,
David A., Safe Storage of Laboratory Chemicals, Wiley & Sons, Inc. 1984.
Code
of Federal Regulations, 29 CFR part 1910 subpart Z section 1910.1450, Occupational
Exposure to Hazardous
Chemicals in Laboratories, 1990.
Standard Operating
Procedure (example)
Standard Operating Procedures
for Hazardous Chemicals
MTU Safety Manual @ http://www.admin.mtu.edu/fm/oshs/manual.htm
CEE Dept. Chemical Hygiene
Plan @ http://www.civil.mtu.edu/docu/rtknow/rttoknow.html
Civil and Environmental Engineering, Michigan Technological University
|
Date: |
Nov
15, 1999 |
|
|
|
Room
and Building: |
Dillman B004 |
|
|
|
Lab
Supervisor: |
Tom
Van Dam |
|
|
|
Office
Phone #: |
906-487-2524
|
|
|
|
#
pages: |
2 |
|
|
#1 PROCESS
Extracting petroleum asphalt from pavement samples.
#2 HAZARDOUS CHEMICALS/CLASS
OF HAZARDOUS CHEMICALS
Trichloroethene (TCE)
#3 PERSONAL PROTECTIVE
EQUIPMENT
Safety goggles – ANSI Z87.1-1989
Suggested
Glove Type Model Number Thickness Breakthrough Time
PVA Edmont 25-545 0.38 mm 480 min
Viton North F-091
0.25mm 390 min
Butyl rubber North
B-174 0.64mm 10 min
Nitrile North LA-142G 0.36mm 4 min
Wear above listed personal protective equipment when
working with Trichloroethene.
#4 ENGINEERING/VENTILATION
CONTROLS
Use in ventilated area.
#5 SPECIAL HANDLING
PROCEDURES AND STORAGE REQUIREMENTS
Keep containers closed when not in use.
#6 SPILL AND ACCIDENT
PROCEDURES
EYE CONTACT: Immediately flush eyes with cool flowing water continuously for 15 minutes, lifting eyelids occasionally. Immediately call for medical attention.
SKIN CONTACT: Remove contaminated clothing. Wash contact area with mild soap and water. Rinse thoroughly. Seek medical attention if skin rash persists.
IF
INHALED: remove to fresh air.
Small Spill: Do not attempt cleanup if
you feel unsure of your ability to do so or if you perceive the risk to be
greater than normal laboratory operations.
Do not exceed the PEL of 100 ppm or the ceiling limit of 300 ppm during
cleanup activities. If you are
confident in your ability to clean up the spill, pick up the liquid with
absorbent and place in appropriate storage containers (see CHP 2.2.2). Make
sure spilled chemical is compatible with other chemicals that may be in
designated storage container.
Large Spill: Notify others in area of
spill. Evacuate area, dial 123, notify second knowledgeable source, remain in
area in safe location to restrict access and assist with response.
#7 WASTE DISPOSAL
Disposal
of liquid/solid spilled waste: Hold for
waste disposal authorization/pickup by MTU OSHS per MTU Civil & Env.
Engineering Chemical Hygiene Plan.
#8 PERMIT APPROVAL REQUIRED
YES (carcinogen and possible mutagen)
#9 DECONTAMINATION
Wash
area with soap and water. Ventilate area. Wash clothing before reuse.
#10 DESIGNATED AREA
YES (
carcinogen and possible mutagen)
Material Safety Data Sheet
(example)
TRICHLOROETHYLENE
MSDS Number: T4940
--- Effective Date: 09/14/00
1. Product
Identification
Synonyms:
Trichloroethene; TCE; acetylene trichloride; Ethinyl trichloride
CAS No.: 79-01-6
Molecular Weight: 131.39
Chemical Formula: C2HCl3
Product Codes:
J.T. Baker: 5376, 9454, 9458, 9464, 9473,
9474
Mallinckrodt: 8598, 8600, 8633
2.
Composition/Information on Ingredients
Ingredient CAS No Percent
Hazardous
Trichloroethylene 79-01-6 100% Yes
3. Hazards
Identification
Emergency Overview
--------------------------
WARNING! HARMFUL IF
SWALLOWED OR INHALED. AFFECTS HEART, CENTRAL NERVOUS SYSTEM, LIVER AND
KIDNEYS. CAUSES
SEVERE SKIN IRRITATION. CAUSES IRRITATION TO EYES AND RESPIRATORY TRACT.
SUSPECT CANCER
HAZARD. MAY CAUSE CANCER. Risk of cancer depends on level and duration of
exposure.
J.T. Baker
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-------------------------------------------------------------------------------------------
Health Rating: 3 -
Severe (Cancer Causing)
Flammability Rating:
1 - Slight
Reactivity Rating: 1
- Slight
Contact Rating: 2 -
Moderate
Lab Protective Equip:
GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVES
Storage Color Code:
Blue (Health)
--------------------------------------------------------------------------------------------
Potential Health
Effects
Inhalation:
Vapors can irritate
the respiratory tract. Causes depression of the central nervous system with
symptoms of visual disturbances and mental confusion, incoordination, headache,
nausea, euphoria, and dizziness. Inhalation of high concentrations could cause
unconsciousness, heart effects, liver effects, kidney effects, and death.
Ingestion:
Cases irritation to
gastrointestinal tract. May also cause effects similar to inhalation. May cause
coughing, abdominal pain, diarrhea, dizziness, pulmonary edema,
unconsciousness. Kidney failure can result in severe cases. Estimated fatal
dose is 3-5 ml/kg.
Skin Contact:
Cause irritation,
redness and pain. Can cause blistering. Continued skin contact has a defatting
action and can produce rough, dry, red skin resulting in secondary infection.
Eye Contact:
Vapors may cause
severe irritation with redness and pain. Splashes may cause eye damage.
Chronic Exposure:
Chronic exposures may
cause liver, kidney, central nervous system, and peripheral nervous system
effects. Workers chronically exposed may exhibit central nervous system
depression, intolerance to alcohol, and increased cardiac output. This material
is linked to mutagenic effects in humans. This material is also a suspect carcinogen.
Aggravation of
Pre-existing Conditions:
Persons with
pre-existing skin disorders, cardiovascular disorders, impaired liver or kidney
or respiratory function, or central or peripheral nervous system disorders may
be more susceptible to the effects of the substance.
4. First Aid Measures
Inhalation:
Remove to fresh air.
If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Call a physician.
Ingestion:
Induce vomiting
immediately as directed by medical personnel. Never give anything by mouth to
an unconscious person. Call a physician.
Skin Contact:
Immediately flush
skin with plenty of soap and water for at least 15 minutes while removing
contaminated clothing and shoes. Get medical attention. Wash clothing before
reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush
eyes with plenty of water for at least 15 minutes, lifting lower and upper
eyelids occasionally. Get medical attention immediately.
Note to Physician:
Do not administer
adrenaline or epinephrine to a victim of chlorinated solvent poisoning.
5. Fire Fighting
Measures
Fire:
Autoignition
temperature: 420C (788F)
Flammable limits in
air % by volume:
lel: 8; uel: 12.5
Explosion:
A strong ignition
source, e. g., a welding torch, can produce ignition. Sealed containers may
rupture when heated.
Fire Extinguishing
Media:
Use water spray to
keep fire exposed containers cool. If substance does ignite, use CO2, dry
chemical or foam.
Special Information:
In the event of a
fire, wear full protective clothing and NIOSH-approved self-contained breathing
apparatus with full facepiece operated in the pressure demand or other positive
pressure mode. Combustion by-products include phosgene and hydrogen chloride
gases. Structural firefighters' clothing provides only limited protection to
the combustion products of this material.
6. Accidental Release
Measures
Ventilate area of
leak or spill. Remove all sources of ignition. Wear appropriate personal
protective equipment as specified in Section 8. Isolate hazard area. Keep
unnecessary and unprotected personnel from entering. Contain and recover liquid
when possible. Use non-sparking tools and equipment. Collect liquid in an
appropriate container or absorb with an inert material (e. g., vermiculite, dry
sand, earth), and place in a chemical waste container. Do not use combustible
materials, such as saw dust. Do not flush to sewer! US Regulations (CERCLA)
require reporting spills and releases to soil, water and air in excess of
reportable quantities. The toll free number for the US Coast Guard National
Response Center is (800) 424-8802.
7. Handling and
Storage
Keep in a tightly
closed container, stored in a cool, dry, ventilated area. Protect against
physical damage. Isolate from any source of heat or ignition. Isolate from
incompatible substances. Containers of this material may be hazardous when
empty since they retain product residues (vapors, liquid); observe all warnings
and precautions listed for the product.
8. Exposure
Controls/Personal Protection
Airborne Exposure
Limits:
Trichloroethylene:
-OSHA Permissible Exposure Limit (PEL):
100 ppm (TWA), 200
ppm (Ceiling),
300 ppm/5min/2hr
(Max)
-ACGIH Threshold
Limit Value (TLV):
50 ppm (TWA) 100 ppm
(STEL);
listed as A5, not
suspected as a human carcinogen.
Ventilation System:
A system of local
and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local
exhaust ventilation is generally preferred because it can control the emissions
of the contaminant at its source, preventing dispersion of it into the general
work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual
of Recommended Practices, most recent edition, for details.
Personal Respirators
(NIOSH Approved):
If the exposure limit
is exceeded and engineering controls are not feasible, wear a supplied air,
full-facepiece respirator, airlined hood, or full-facepiece self-contained
breathing apparatus. Breathing air quality must meet the requirements of the
OSHA respiratory protection standard (29CFR1910.134). This substance has poor
warning properties. Where respirators are required, you must have a written
program covering the basic requirements in the OSHA respirator standard. These
include training, fit testing, medical approval, cleaning, maintenance,
cartridge change schedules, etc. See 29CFR1910.134 for details.
Skin Protection:
Wear impervious
protective clothing, including boots, gloves, lab coat, apron or coveralls, as
appropriate, to prevent skin contact. Neoprene is a recommended material for
personal protective equipment.
Eye Protection:
Use chemical safety
goggles and/or a full face shield where splashing is possible. Maintain eye
wash fountain and quick-drench facilities in work area.
9. Physical and
Chemical Properties
Appearance:
Clear, colorless
liquid.
Odor:
Chloroform-like odor.
Solubility:
Practically insoluble
in water. Readily miscible in organic solvents.
Specific Gravity:
1.47 @ 20C/4C
pH:
No information found.
% Volatiles by volume
@ 21C (70F): 100
Boiling Point:
87C (189F)
Melting Point:
-73C (-99F)
Vapor Density
(Air=1): 4.5
Vapor Pressure (mm
Hg):
57.8 @ 20C (68F)
Evaporation Rate
(BuAc=1):
No information found.
10. Stability and
Reactivity
Stability:
Stable under ordinary
conditions of use and storage. Will slowly decompose to hydrochloric acid when
exposed to light and moisture.
Hazardous
Decomposition Products:
May produce carbon
monoxide, carbon dioxide, hydrogen chloride and phosgene when heated to
decomposition.
Hazardous
Polymerization:
Will not occur.
Incompatibilities:
Strong caustics and
alkalis, strong oxidizers, chemically active metals, such as barium, lithium,
sodium, magnesium, titanium and beryllium, liquid oxygen.
Conditions to Avoid:
Heat, flame, ignition
sources, light, moisture, incompatibles
11. Toxicological
Information
Toxicological Data:
Trichloroethylene:
Oral rat LD50: 5650 mg/kg; investigated as a tumorigen, mutagen, reproductive
effector.
Reproductive
Toxicity:
This material has
been linked to mutagenic effects in humans.
--------\Cancer
Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known
Anticipated IARC Category
Trichloroethylene (79-01-6) No Yes 2A
12. Ecological
Information
Environmental Fate:
When released into
the soil, this material may leach into groundwater. When released into the
soil, this material is expected to quickly evaporate.
When released to
water, this material is expected to quickly evaporate. This material has an
experimentally-determined bioconcentration factor (BCF) of less than 100. This
material is not expected to significantly bioaccumulate. When released into the
air, this material may be moderately degraded by reaction with photochemically
produced hydroxyl radicals. When released into the air, this material is
expected to have a half-life between 1 and 10 days.
Environmental
Toxicity:
The LC50/96-hour
values for fish are between 10 and 100 mg/l. This material is expected to be
slightly toxic to aquatic life.
13. Disposal
Considerations
Whatever cannot be
saved for recovery or recycling should be handled as hazardous waste and sent
to a RCRA approved incinerator or disposed in a RCRA approved waste facility.
Processing, use or contamination of this product may change the waste
management options. State and local disposal regulations may differ from federal
disposal regulations. Dispose of container and unused contents in accordance
with federal, state and local requirements.
14. Transport
Information
Domestic (Land,
D.O.T.)
Proper Shipping Name:
TRICHLOROETHYLENE
Hazard Class: 6.1
UN/NA: UN1710
Packing Group: III
Information reported
for product/size: 5GL
International (Water,
I.M.O.)
Proper Shipping Name:
TRICHLOROETHYLENE
Hazard Class: 6.1
UN/NA: UN1710
Packing Group: III
Information reported
for product/size: 5GL
International (Air,
I.C.A.O.)
-----------------------------
Proper Shipping Name:
TRICHLOROETHYLENE
Hazard Class: 6.1
UN/NA: UN1710
Packing Group: III
Information reported
for product/size: 5GL
15. Regulatory
Information
--------\Chemical Inventory Status - Part
1\---------------------------------
Ingredient TSCA EC
Japan Australia
Trichloroethylene (79-01-6) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part
2\---------------------------------
--Canada--
Ingredient Korea DSL
NDSL Phil.
Trichloroethylene (79-01-6) Yes Yes No Yes
--------\Federal, State & International
Regulations - Part 1\--------------
-SARA 302- ------SARA
313------
Ingredient RQ TPQ List
Chemical Catg.
Trichloroethylene (79-01-6) No
No Yes No
--------\Federal, State & International
Regulations - Part 2\--------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
Trichloroethylene (79-01-6) 100 U228 No
Chemical Weapons
Convention: No TSCA 12(b):
No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire:
No Pressure: No
Reactivity: No (Pure / Liquid)
WARNING:
THIS PRODUCT CONTAINS
A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER.
Australian Hazchem
Code: No information found.
Poison Schedule: S6
WHMIS:
This MSDS has been
prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the
CPR.
16. Other Information
NFPA Ratings: Health:
2 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF
SWALLOWED OR INHALED. AFFECTS HEART, CENTRAL NERVOUS SYSTEM, LIVER AND KIDNEYS.
CAUSES SEVERE SKIN IRRITATION. CAUSES IRRITATION TO EYES AND RESPIRATORY TRACT.
SUSPECT CANCER HAZARD. MAY CAUSE CANCER. Risk of cancer depends on level and
duration of exposure.
Label Precautions:
Do not get in eyes,
on skin, or on clothing.
Do not breathe vapor.
Keep container
closed.
Use only with
adequate ventilation.
Wash thoroughly after
handling.
Keep away from heat
and flame.
Label First Aid:
If swallowed, induce
vomiting immediately as directed by medical personnel. Never give anything by
mouth to an unconscious person. If inhaled, remove to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
In case of contact, immediately flush eyes or skin with plenty of water for at
least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before
reuse. In all cases call a physician.
Note to physician: Do
not administer adrenaline or epinephrine to a victim of chlorinated solvent
poisoning.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s)
changed since last revision of document include: 8, 11.
Disclaimer:
******************************************************************************
Mallinckrodt Baker,
Inc. provides the information contained herein in good faith but makes no
representation as to its comprehensiveness or accuracy. This document is
intended only as a guide to the
appropriate precautionary handling of the material by a properly trained
person using this product. Individuals receiving the information must exercise their independent judgment in
determining its
appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO
REPRESENTATIONS
OR WARRANTIES, EITHER
EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE
INFORMATION SET FORTH
HEREIN OR THE PRODUCT
TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER,
INC. WILL NOT BE
RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
******************************************************************************
Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)
Chemical Storage and Classification System (Flynn Scientific Inc. System)
Suggested Shelf
Storage Pattern – Inorganic
The following order
presented should be from the top shelf of the cabinet to bottom shelf.
Cabinet 1
I – 10
Sulfur, Phosphorous,
Arsenic, Phosphorous Pentoxide
I – 2
Halides, Sulfates,
Sulfites, Thiosulfates, Phosphates, Halogens, Acetates
I – 3
Amides, Nitrates (not
Ammonium Nitrate), Nitrites, Azides
I – 1
Metals and Hydrides
I – 4
Hydroxides, Oxides,
Silicates, Carbonates, Carbon
Cabinet 2
I – 7
Arsenates, Cyanides,
Cyanates
I – 5
Sulfides, Selenides,
Phosphides, Carbines, Nitrides
I – 8
Borates, Chromates,
Manganates, Permangantes
I – 6
Bromates, Chlorates,
Perchlorates, Chlorites, Perchloric Acid, Peroxides, Hypochlorites, Hydrogen
Peroxide
Cabinet 3
I – 9
Acids, except Nitric
Cabinet 4
O – 2
Alcohols, Glycols,
Amines, Amides, Imines, Imides
O – 3
Hydrocarbons, Esters,
Aldehydes
O – 4
Ethers, Ketones,
Detenes, Halogenated Hydrocarbons, Ethylene Oxide
O – 5
Epoxy Compounds,
Isocyanates
O – 7
Sulfides,
Polysulfides, etc.
Cabinet 5
O – 8
Phenols, Cresols
O – 6
Peroxides, Azides,
Hydroperoxides
O – 1
Acids, anhydrides,
Peracides
Cabinet 6
O – 2
Alcohols, Glycols,
etc.
O – 3
Hydrocarbons, Esters,
etc.
O – 4
Ethers, Ketones, etc.
Cabinet 6
Severe Poisons
Date: November 9, 1993
TO: Faculty, Graduate Students and Staff in the Chemical Engineering, Chemistry & Environmental Engineering Departments
From: Chemical Sciences & Engineering Building Safety Committee
RE: Revised Policy for Teaching/Research Laboratory Glassware Disposal
Signed WM Blumhardt
In order to reduce the numerous steps currently involved in the laboratory glass disposal process and associated risk of a serious accident to either our Building Custodians and/or other individuals in our buildling, listed below is a revised policy for glassware disposal from our teaching/research laboratories.
1. An appropriate glass disposal box (GDB) for broken glassware needs to be located within each teaching/research lab.
2. A GDB can be purchased for $5.31 from Chem Stores, Catalog #00142.
3. Each GDB can only be used one time – you cannot keep replacing only the liner as in the past.
4. All broken glassware should be immediately disposed of in the GDB.
Large unbroken empty glass jugs, which have been rinsed with water, can be placed next to the GDB for collection by the custodian. DO NOT PLACE IN THE HALLWAYS.
5.
Glassware which contain chemicals such as mercury in
thermometers must be disposed of in their own containers, labeled appropriates
as well as covered by a lid, and disposed of in accordance with University OSHS
procedures. DO NOT PUT IN THE
GDB.
6.
When the GDB is full please leave a note on the outside of the
GDB for the custodian that it is ready to be picked up for disposal.
CUSTODIANS HAVE BEEN INSTRUCTED TO ONLY PICK UP GLASS FOR DISPOSAL WHICH IS CONTAINED IN A GDB.
7. All hallways and exits have to be kept free from obstructions in the event of a building emergency evacuation. Boxes or other refuse should be placed next to the GDB in your lab and labeled trash on the outside for the custodian who will pick it up for disposal.
8. Any materials being stored prior to disposal should be placed in the loading dock area. Special care should be taken to not obstruct access to the gas cylinder storage cages.
Thank you for your cooperation
C: Building Custodians
Unattended Operations Notice
Operation: (example) Heat conditioning Diffusion Denuder under constant
nitrogen purge.
Start Date/Time:
End Date/Time:
Location: (example) Dow 835, Inside Hood
Hazard: (example) Compressed Gas
(nitrogen)
Electrical
Shock
High
Temperature (300C)
In Case of Emergency Contact Public Safety ext. 123
For question or concerns, contact:
John Doe
Office Dow 830
Phone 7-2222 (work)
483-2222 (home)
Jane Dow
Office Dow 831
Phone 7-5555 (work)
483-5555 (home)
Date:
Room:
Impact
Chipping, grinding, machining,
woodworking, sawing, drilling
Specific Equipment Required _____________________________________________________________________
Chemical
Exposure
Acid and chemical handling, vapors, degreasing solvents,
battery handling, etc.
Specific Equipment Required________________________________________________
Sharp Objects
Broken or chipped glass, handling sharp edged parts, objects
which may pierce or cut a foot or hand, etc.
Specific Equipment Required _____________________________________________________________________
Temperature
Extremes
Working areas where
hot temperatures could cause burns, eye injury or ignite PPE and working areas
where cold temperatures could cause frostbite or hypothermia.
Specific Equipment Required _____________________________________________________________________
Rolling
Objects
Working in areas
where the potential for rolling objects to pinch or crush hands or feet exists.
Specific Equipment Required____________________________________________
Falling,
Dropping or Bumping Objects
Working in areas
where the potential for falling objects and /or bumping hazards exists.
Specific Equipment Required _____________________________________________________________________
Light or
Radiation
Welding, cutting,
brazing, torch soldering, heat treating, high intensity lights, x-rays, handing
of radioisotopes, etc.
Specific Equipment Required _____________________________________________________________________
Respiratory
Any harmful dust,
mist, fume or vapor that could become airborne, posing an inhalation hazard.
Specific Equipment Required _____________________________________________________________________
Electrical
Direct or indirect
contact with electricity.
Specific Equipment Required _____________________________________________________________________
Does the
facility layout and co-worker position or location pose a hazard? If yes, describe the hazard that exists.
________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
Specific
Equipment Required
__________________________________________________
Glove Selection
Proper glove
selection can be performed by accessing the following website.
http://www.anellpro.com/us/html/home.asps
http://www.chemREST.com/netscape/select_chemical_by_name.htm#CAS
A CD is also
available from chemRest, see your Chemical Hygiene Officer for a copy if you
are not able to access one of these sites.
It is very important
when selecting a glove to purchase the exact glove referenced by the
manufacture as this data is specific to the manufacturer. It is possible to purchase nearly the identical
glove from a different manufacturer but you must verify the rating with that
manufacturer as manufacturers may use different manufacturing process, such as
different techniques for sealing seams on gloves, that could significantly
effect the performance of the glove.
The following is an
example from Ansell:
Chemical:
Benzene
CAS No.:
71-43-2
Synonyms:
Benzene
Benzol
Color Code Click on the Glove Types below to get the
specific glove recommendations.
Degradation Permeation Permeation
Gray Glove Type Rating Breakthrough
Rate
Supported Nitrile
(Sol-Knit) --
-- --
Red Unsupported Nitrile
(Sol-Vex) P -- --
Red Unsupported
Neoprene NR -- --
Red Supported Neoprene
(Neox, Scorpio) NR -- --
Green Supported Polyvinyl
Alcohol (PVA) E >360 E
Red Polyvinyl
Chloride(PVC) NR --
--
Red Natural Rubber
(Latex) NR -- --
Red Neoprene/Latex
(Chemi-Pro) NR -- --
Green Barrier Chemical
Resistant * >480 E
None Thin Mil Nitrile Click
Here for Thin Mil Nitrile Information
Color Code LEGEND
Green The Glove is very well suited
for application with that
chemical.
Yellow The Glove is suitable for that application
under careful
control of its use.
Red Avoid use of the glove with
this chemical.
Gray The glove is untested for use
with this chemical.
Hazard Statement
The goal of defining
precisely, in measurable terms, every possible health or physical effect that
may occur in the workplace as a result of chemical exposures cannot
realistically be accomplished. This does not negate the need for employees to
be informed of such effects and protected from them. The following outlines
principles and procedures of hazard assessment.
For purposes of this
section; any chemical which meets any of the following definitions are
considered hazards and should be labeled with the following words defined below
in bold.
(1) "Carcinogen:"
A
chemical is considered to be a carcinogen if:
(a) It has been evaluated by the International Agency for
Research on Cancer (IARC), and found to be a carcinogen or potential
carcinogen; or
(b) It is listed as a carcinogen or potential carcinogen in the
Annual Report on Carcinogens published by the National Toxicology Program (NTP)
(latest edition); or,
(c) It is regulated by OSHA as a carcinogen.
(2) "Corrosive:"
A
chemical that causes visible destruction of, or irreversible alterations in,
living tissue by chemical action at the site of contact. For example, a chemical is considered to be
corrosive if, when tested on the intact skin of albino rabbits by the method
described by the U. S. Department of Transportation in appendix A to 49 CFR
part 173, it destroys or changes irreversibly the structure of the tissue at
the site of contact following an
exposure period of four hours. This term shall not refer to action on
inanimate surfaces.
(3) "Highly toxic:"
A
chemical falling within any of the following categories:
(a) A chemical that has a median lethal dose (LD50 ) of 50
milligrams or less per kilogram of body weight when administered orally to
albino rats weighing between 200 and 300 grams each.
(b) A chemical that has a median lethal dose (LD50 ) of 200
milligrams or less per kilogram of body weight when administered by continuous
contact for 24 hours (or less if death occurs within 24 hours) with the bare
skin of albino rabbits weighing between two and three kilograms each.
(c) A chemical that has a median lethal concentration (LC50 ) in
air of 200 parts per million by volume or less of gas or vapor, or 2 milligrams
per liter or less of mist, fume, or dust, when administered by continuous
inhalation for one hour (or less if death occurs within hour) to albino rats
weighing between 200 and 300 grams each.
(4) "Irritant:"
A
chemical, which is not corrosive, but which causes a reversible inflammatory
effect on living tissue by chemical action at the site of contact. A chemical
is a skin irritant if, when test4ed on the intact skin of albino rabbits by the
methods of 16 CFR 1500.41 for four hours exposure or by other appropriate
techniques, it results in an empirical score of five or more. A chemical is an
eye irritant if so determined under the procedure listed in 16 CFR 1500.42 or
other appropriate techniques.
(5) "Sensitizer:"
A
chemical that causes a substantial proportion of exposed people or animals to
develop an allergic reaction in normal tissue after
repeated exposure to the chemical.
(6) "Toxic:"
A
chemical falling within any of the following categories:
A chemical that has a median lethal dose (LD50 ) of more
than 50 milligrams per kilogram but not more than 500 milligrams per kilogram of body weight when administered orally
to albino rats weighing between 200 and 300 grams each.
(A) A chemical that has a median lethal dose (LD50 ) of more
than 200 milligrams per kilogram but not more than 1,000 milligrams per
kilogram of body weight when administered by continuous contact for 24 hours (or
less if death occurs within 24 hours) when the bare skin of albino rabbits
weighing between two and three kilograms each.
(B) A chemical that has a median lethal concentration (LC50 ) in
air of more than 200 parts per million but not more than 2,000 parts per
million by volume of gas or vapor, or more than two milligrams per liter but
not more than 20 milligrams per liter of mist, fume, or dust, when administered
by continuous inhalation for one hour (or less if death occurs within one hour)
to albino rats weighing between 200 or 300 grams each.
(7) "Target organ effects."
The
following is a target organ categorization of effects which may occur,
including examples of signs and symptoms and chemicals which have been found to
cause such effects. These examples are presented to illustrate the range and
diversity of effects and hazards found in the workplace, and the broad scope
employers must consider in this area, but are not intended to be all-inclusive.
(A) Hepatotoxins: chemicals which produce liver damage. Signs
& Symptoms: Jaundice; liver enlargement. Chemicals: Carbon tetrachloride;
nitrosamines.
(B) Nephrotoxins: Chemicals which produce kidney damage. Signs
& symptoms: Edema; proteinuria. Chemicals: Halogenated hydrocarbons;
uranium.
(C) Neurotoxins: Chemicals which produce their primary toxic
effects on the nervous system. Signs & Symptoms: Narcosis; behavioral
changes; decrease in motor functions.
(D) Agents which act on the blood or hematopoietic system:
Decrease hemoglobin function; deprive the body tissues of oxygen. Signs &
Symptoms: Cyanosis; loss of consciousness. Chemicals: Carbon monoxide;
cyanides.
(E) Agents which damage the lung: Chemicals which irritate or
damage pulmonary tissue. Signs & Symptoms: Cough; tightness in chest;
shortness of breath. Chemicals: Silica; asbestos.
(F) Reproductive toxins: Chemicals which affect the reproductive
capabilities include chromosomal damage (mutations) and effects on fetuses
(teratogenesis). Signs & Symptoms: Birth defects; sterility. Chemicals:
Lead; DBCP.
(G) Cutaneous hazards: Chemicals which affect the dermal layer
of the body. Signs & Symptoms: Birth defects; sterility. Chemicals: Lead;
DBCP.
(H) Eye hazards: chemicals which affect the eye or visual
capacity. Signs & symptoms: Conjunctives; corneal damage. Chemicals: Organic
solvents; acids.
(8)"Compressed
gas":
(A) A gas or mixture of gases having, in a container, an
absolute pressure exceeding 40 psi at 70 deg. F (21.1 deg. C); or
(B) A gas or mixture of gases having, in a container, an
absolute pressure exceeding 104 psi at 130 deg. F (54.4 deg. C) regardless of
the pressure at 70 deg. F (21.1 deg. C); or
(C) A liquid having a vapor pressure exceeding 40 psi at 100
deg. F (37.8 deg. C) as determined by ASTM D-323-72.
(9)"Explosive":
(A) A chemical that causes a sudden almost instantaneous release
of pressure, gas, and heat when subjected to sudden shock, pressure, or high
temperature.
(10)"Flammable":
A
chemical that falls into one of the following categories:
(A) "Aerosol, flammable"
An aerosol that, when tested by the method described in 16
CFR 1500.45, yields a flame projection exceeding 18 inches at full valve
opening, or a flashback (a flame extending back to the valve) at any degree of
valve opening;
(B) "Gas, flammable:
(1) A gas that, at ambient temperature and pressure, forms a
flammable mixture with air at a concentration of thirteen (13) percent by
volume or less; or
(2) A gas that, at ambient temperature and pressure, forms a
range of flammable mixtures with air wider than twelve (12) percent by volume,
regardless of the lower limit;
(C)"Liquid, flammable"
Any liquid having a flashpoint below 100 deg. F (37.8 deg.
C), except any mixture having components with flashpoints of 100 deg. F (37.8
deg. C) or higher, the total of which make up 99 percent or more of the total
volume of the mixture.
(D)"Solid, flammable"
A solid, other than a blasting agent or explosive as defined
in 1910.109( a), that is liable to cause fire through friction, absorption of
moisture, spontaneous chemical change, or retained heat from manufacturing or
processing, or which can be ignited readily and when ignited burns so
vigorously and persistently as to create a serious hazard. A chemical shall be
considered to be flammable solid if, when tested by the method described in 16
CFR 1500.44, it ignites and burns with a self-sustained flame at a rate greater
than one-tenth of an inch per second along its major axis.
(11)"Organic
peroxide"
An
organic compound that contains the bivalent-O-O-structure and which may be
considered to be a structural derivative of hydrogen peroxide where one or both
of the hydrogen atoms has been replaced by an organic radical.
(12)"Oxidizer"
Chemical
other than a blasting agent or explosive as defined in 1910.109( a), that
initiates or promotes combustion in other materials, thereby causing fire
either of itself or through the release of oxygen or other gases.
(13)"Pyrophoric"
A
chemical that will ignite spontaneously in air at a temperature of 130 deg. F
(54.4 deg. C) or below.
(14)"Unstable
(reactive)"
A
chemical which in the pure state, or as produced or transported, will
vigorously polymerize, decompose, condense, or will become self-reactive under
conditions of shocks, pressure or temperature.
(15)"Water-reactive"
A
chemical that reacts with water to release a gas that is either flammable or
presents a health hazard.
If an emergency
occurs please contact the following persons or departments in the order
presented:
Campus Emergency
Number 123
Public Safety
Dr. Niemi 487-2118
Manager, Occupational
Safety and Health Services 482-9017 (home)
David Perram 487-2713
Chemical Hygiene
Officer 337-1786
(home)
Chris Wojick 487-1623
Safety Officer 482-6075
(home)
Robert Baillod 487-2520
Department Head, CEE 482-3240
(home)
Off-Campus Shipping of Chemicals, Wastes, Samples, or
Testing Materials
http://www.admin.mtu.edu/fm/oshs/section10.htm
10.5 Shipping
Hazardous Materials
Shipments of
hazardous materials such as explosives, compressed gases, flammable solids and
liquids, oxidizers, toxic and infectious materials, radioactive materials,
corrosive substances, and environmental pollutants are regulated by the
Department of Transportation, DOT, regardless of quantity. Employees who offer
such materials for shipment as well as those responsible for receiving
shipments must be trained in accordance with DOT regulations. Contact
Occupational Safety and Health Services for information and assistance with
training and shipments of materials that could potentially be regulated.
Definition of Hazardous Waste
D001: Flash point less than
60oC
D003:
1)
normally unstable
2) readily undergoes violent changes without detonation
3)
reacts violently, forms explosive mixture and/or generates toxic gases with
water
4) cyanide or sulfur bearing waste
D004 – D043: Table
of compounds, commonly known as the Toxicity Characteristic Leaching Procedure
(TCLP) list.
P-List: Unused
chemical (i.e. discarded commercial chemicals, container residues, spill
residues, etc. not mixed with second active ingredient) which are present in
quantities less than or equal to 1 liter or 1 kilogram
U-List: Unused
chemical wastes (similar to P-List) which are present in quantities greater
than 1 liter or 1 kilogram
F-List: Hazardous
wastes (reaction products)
Federal Laws Prohibit
Improper Disposal
If found, contact the
nearest police or Public Safety Authority or the U.S. Environmental Protection
Agency
Generator
Information:
Name: Michigan Technological University
Address: 1400 Townsend Drive
City: Houghton State: Michigan Zip: 49931
EPA Identification
Number: MID065453268
EPA Waste Number:
Accumulation Start
Date:
Requested by:
Department: Civil and
Environmental Engineering
Location of Material:
Room Number:
Date:
Phone:
Approved by:
__________________________________________________________
Department Chair Civil and Environmental Engineering
Item Hazard
Class Physical
Number Name Code State Code Quantity____
1
2
3
4 5
6
7
8
9
10
Codes
Physical State: Sol = Solid, Liq = Liquid, gas Slu
= Sludge
Hazard Class: F = Flammable, C = Corrosive, T =
Toxic, E = Explosive,
M = Mutagenic,
Teratogenic, or Carconogenic, A = Reacts violently with air,
B = Reacts violently
with water
http://ehp.niehs.nih.gov/roc/
Know to be human
carcinogens:
Aflatoxins
Alcoholic Beverage
Consumption
4-Aminobiphyenyl
(4-aminodiphenyl)
2-Aminonaphtlalene
(see 2-Naphthylamine)
Analgesic Mixtures
Containing Phenacetin
Arsenic Compounds,
Inorganic
Asbestos
Azathioprine
Benzene
Benzidine
Bis(Chloromethyl)
Ether
Busulfan (see
1,4-Butanediol Dimethylsulfonate)
1,3-Butadiene
1,4-Butanediol
Dimethylsulfante (Myleran; Busulfan)
Cadmium (under
cadmium and cadmium compounds)
Cadmium Chloride
(under cadmium and cadmium compounds)
Cadmium Oxide (under
cadmium and cadmium compounds)
Cadmium sulfate
(under cadmium and cadmium compounds)
Cadmium Sulfide
(under cadmium and cadmium compounds)
Chlorambucil
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
(MeCCNU)
Chloromethyl Methyl
Ether
Chromium Hexavalent
Compounds (under Chromium Hexavalent Compounds)
Coal Tar (under Tares
and Mineral Oils)
Coke Oven Emissions
Creosote (Coal) (under Tars and Mineral Oils)
Creosote (Wood)
(under Tars and Mineral Oils)
Cristobalite (under
Silica, Crystaline (Respirable Size))
Cyclophosphamide
Cyclosporin A
(Cyclosprine A; Circlesporia)
Diethylstibestrol
Direct Black 38
Direct Blue 6
Dyes that Metabize to
Benzidine
Environmental Tobacco
Smoke
Erionite
Ethylene Oxide
Lead Chromate (under
Chromium Hexavalent Compounds)
Melphalan
Methoxsalen (under Methoxsalen
with Ultraviolet A Therapy (PUVA)) (methoxsalen not carcinogenic alone)
Mineral Oils
Mustard Gas
Myleran (see
1,4-Butanediol Dimethylsulfonate)
2-Naphthylamine
(Beta-Naphthylamine; 2-aminonaphthlalene)
Piperzaine Estrone
Sulfate (under Conjugated Estrogens)
Quartz (under Silca,
Crystalline (Respirable Size))
Radon
Silica, Crystalline
(Respirable Size)
Smokeless Tobacco
Sodium Equilin
Sulfate (under Conjugated Estrogens)
Sodium Estrogen
Sulfate (under Conjugated Estrogens)
Solar Radiation and
Exposure to Sunlamps and Sunbeds
Soots
Strong Inorganic Acid
Mists Containing Sulfuric Acid
Strontium Chromate
(under Chromium Hexavalent Compounds)
Tamoxifen
Tars
Thiotepa (in 7th
ARC as tris(1-Aziridinyl)phosphine Sulfide)
Thorium Dioxide
Tobacco Smoking
Tridymite (under
Silica, Crystalline (Respirable Size)
Tris(1-azirdinyl)phosopine
Sulfide (Thiotepa)
Vinyl Chloride
Zinc Chromate (under
Chromium Hexavalent Compounds)
http://monographs.iarc.fr/
Overall Evaluations
of Carcinogenicity to Humans
Group 1: Carcinogenic to humans
This list contains
all agents, mixtures and exposures evaluated as being in Group 1 to date. Where appropriate, chemical abstract numbers
are given [in square brackets]. For details of the evaluation, the relevant Monograph
should be consulted (volume number given in round brackets, followed by year of
publication of latest evaluation). Use a free-text search to find a particular
compound.
Agents and groups of
agents
Aflatoxins, naturally
occurring [1402-68-2] (Vol. 56; 1993)
4-Aminobiphenyl
[92-67-1] (Vol. 1, Suppl. 7; 1987)
Arsenic [7440-38-2]
and arsenic compounds (Vol. 23, Suppl. 7; 1987)
(NB: This evaluation
applies to the group of compounds as a whole and not necessarily to all
individual compounds within the group)
Asbestos [1332-21-4]
(Vol. 14, Suppl. 7; 1987)
Azathioprine
[446-86-6] (Vol. 26, Suppl. 7; 1987)
Benzene [71-43-2]
(Vol. 29, Suppl. 7; 1987)
Benzidine [92-87-5]
(Vol. 29, Suppl. 7; 1987)
Beryllium [7440-41-7]
and beryllium compounds (Vol. 58; 1993)
(NB: Evaluated as a
group)
N,N-Bis(2-chloroethyl)-2-naphthylamine
(Chlornaphazine) [494-03-1] (Vol. 4, Suppl. 7; 1987)
Bis(chloromethyl)ether
[542-88-1] and chloromethyl methyl ether [107-30-2] (technical-grade)
(Vol. 4, Suppl. 7;
1987)
1,4-Butanediol dimethanesulfonate
(Busulphan; Myleran) [55-98-1] (Vol. 4, Suppl. 7; 1987)
Cadmium [7440-43-9]
and cadmium compounds (Vol. 58; 1993)
(NB: Evaluated as a
group)
Chlorambucil
[305-03-3] (Vol. 26, Suppl. 7; 1987)
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
(Methyl-CCNU; Semustine) [13909-09-6] (Suppl. 7; 1987)
Chromium[VI]
compounds (Vol. 49; 1990)
(NB: Evaluated as a
group)
Ciclosporin
[79217-60-0] (Vol. 50; 1990)
Cyclophosphamide
[50-18-0] [6055-19-2] (Vol. 26, Suppl. 7; 1987)
Diethylstilboestrol
[56-53-1] (Vol. 21, Suppl. 7; 1987)
Epstein-Barr virus
(Vol. 70; 1997)
Erionite [66733-21-9]
(Vol. 42, Suppl. 7; 1987)
Ethylene oxide
[75-21-8] (Vol. 60; 1994)
(NB: Overall
evaluation upgraded from 2A to 1 with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Etoposide
[33419-42-0] in combination with cisplatin and bleomycin (Vol. 76; 2000)
[Gamma Radiation: see
X- and Gamma (g)-Radiation]
Helicobacter pylori
(infection with) (Vol. 61; 1994)
Hepatitis B virus
(chronic infection with) (Vol. 59; 1994)
Hepatitis C virus
(chronic infection with) (Vol. 59; 1994)
Human
immunodeficiency virus type 1 (infection with) (Vol. 67; 1996)
Human papillomavirus
type 16 (Vol. 64; 1995)
Human papillomavirus
type 18 (Vol. 64; 1995)
Human T-cell
lymphotropic virus type I (Vol. 67; 1996)
Melphalan [148-82-3]
(Vol. 9, Suppl. 7; 1987)
8-Methoxypsoralen
(Methoxsalen) [298-81-7] plus ultraviolet A radiation (Vol. 24, Suppl. 7; 1987)
MOPP and other
combined chemotherapy including alkylating agents (Suppl. 7; 1987)
Mustard gas (Sulfur
mustard) [505-60-2] (Vol. 9, Suppl. 7; 1987)
2-Naphthylamine
[91-59-8] (Vol. 4, Suppl. 7; 1987)
Neutrons (Vol. 75;
2000)
(NB: Overall
evaluation upgraded from 2B to 1 with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Nickel compounds
(Vol. 49; 1990)
(NB: Evaluated as a
group)
Oestrogen therapy,
postmenopausal (Vol. 72; 1999)
Oestrogens, nonsteroidal
(Suppl. 7; 1987)
(NB: This evaluation
applies to the group of compounds as a whole and not necessarily to all
individual compounds within the group)
Oestrogens, steroidal
(Suppl. 7; 1987)
(NB: This evaluation
applies to the group of compounds as a whole and not necessarily to all
individual compounds within the group)
Opisthorchis
viverrini (infection with) (Vol. 61; 1994)
Oral contraceptives,
combined (Vol. 72; 1999)
(NB: There is also
conclusive evidence that these agents have a protective effect against cancers
of the ovary and endometrium)
Oral contraceptives,
sequential (Suppl. 7; 1987)
Phosphorus-32, as
phosphate (Vol. 78; 2001)
Plutonium-239 and its
decay products (may contain plutonium-240 and other isotopes), as aerosols
(Vol. 78; 2001)
Radioiodines,
short-lived isotopes, including iodine-131, from atomic reactor accidents and
nuclear weapons detonation (exposure during childhood) (Vol. 78; 2001)
Radionuclides,
a-particle-emitting, internally deposited (Vol. 78; 2001)
(NB: Specific
radionuclides for which there is sufficient evidence for carcinogenicity to
humans are also listed individually as Group 1 agents)
Radionuclides,
b-particle-emitting, internally deposited (Vol. 78; 2001)
(NB: Specific
radionuclides for which there is sufficient evidence for carcinogenicity to
humans are also listed individually as Group 1 agents)
Radium-224 and its
decay products (Vol. 78; 2001)
Radium-226 and its
decay products (Vol. 78; 2001)
Radium-228 and its
decay products (Vol. 78; 2001)
Radon-222
[10043-92-2] and its decay products (Vol. 78; 2001)
Schistosoma
haematobium (infection with) (Vol. 61; 1994)
Silica [14808-60-7],
crystalline (inhaled in the form of quartz or cristobalite from occupational
sources) (Vol. 68; 1997)
Solar radiation (Vol.
55; 1992)
Talc containing
asbestiform fibres (Vol. 42, Suppl. 7; 1987)
Tamoxifen
[10540-29-1] (Vol. 66; 1996)
(NB: There is also
conclusive evidence that this agent (tamoxifen) reduces the risk of
contralateral breast cancer)
2,3,7,8-Tetrachlorodibenzo-para-dioxin
[1746-01-6] (Vol. 69; 1997)
(NB: Overall
evaluation upgraded from 2A to 1 with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Thiotepa [52-24-4]
(Vol. 50; 1990)
Thorium-232 and its
decay products, administered intravenously as a colloidal dispersion of
thorium-232 dioxide (Vol. 78; 2001)
Treosulfan [299-75-2]
(Vol. 26, Suppl. 7; 1987)
Vinyl chloride
[75-01-4] (Vol. 19, Suppl. 7; 1987)
X- and Gamma
(g)-Radiation (Vol. 75; 2000)
Mixtures
Alcoholic beverages
(Vol. 44; 1988)
Analgesic mixtures
containing phenacetin (Suppl. 7; 1987)
Betel quid with
tobacco (Vol. 37, Suppl. 7; 1987)
Coal-tar pitches
[65996-93-2] (Vol. 35, Suppl. 7; 1987)
Coal-tars [8007-45-2]
(Vol. 35, Suppl. 7; 1987)
Mineral oils,
untreated and mildly treated (Vol. 33, Suppl. 7; 1987)
Salted fish
(Chinese-style) (Vol. 56; 1993)
Shale-oils
[68308-34-9] (Vol. 35, Suppl. 7; 1987)
Soots (Vol. 35,
Suppl. 7; 1987)
Tobacco products,
smokeless (Vol. 37, Suppl. 7; 1987)
Tobacco smoke (Vol.
38, Suppl. 7; 1987)
Wood dust (Vol. 62;
1995)
Exposure
circumstances
Aluminium production
(Vol. 34, Suppl. 7; 1987)
Auramine, manufacture
of (Suppl. 7; 1987)
Boot and shoe
manufacture and repair (Vol. 25, Suppl. 7; 1987)
Coal gasification
(Vol. 34, Suppl. 7; 1987)
Coke production (Vol.
34, Suppl. 7; 1987)
Furniture and cabinet
making (Vol. 25, Suppl. 7; 1987)
Haematite mining
(underground) with exposure to radon (Vol. 1, Suppl. 7; 1987)
Iron and steel
founding (Vol. 34, Suppl. 7; 1987)
Isopropanol
manufacture (strong-acid process) (Suppl. 7; 1987)
Magenta, manufacture
of (Vol. 57; 1993)
Painter (occupational
exposure as a) (Vol. 47; 1989)
Rubber industry (Vol.
28, Suppl. 7; 1987)
Strong-inorganic-acid
mists containing sulfuric acid (occupational exposure to) (Vol. 54; 1992)
Last updated: 5 April
2000
Overall Evaluations
of Carcinogenicity to Humans
Group 2A: Probably carcinogenic to humans
This list contains
all agents, mixtures and exposures evaluated as being in Group 2A to date. Where appropriate, chemical abstract numbers
are given [in square brackets]. For details of the evaluation, the relevant
Monograph should be consulted (volume number given in round brackets, followed
by year of publication of latest evaluation). Use a free-text search to find a
particular compound.
Agents and groups of
agents
Acrylamide [79-06-1]
(Vol. 60; 1994)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Adriamycin
[23214-92-8] (Vol. 10, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Androgenic (anabolic)
steroids (Suppl. 7; 1987)
Azacitidine
[320-67-2] (Vol. 50; 1990)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Benz[a]anthracene
[56-55-3] (Vol. 32, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Benzidine-based dyes
(Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Benzo[a]pyrene
[50-32-8] (Vol. 32, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Bischloroethyl
nitrosourea (BCNU) [154-93-8] (Vol. 26, Suppl. 7; 1987)
1,3-Butadiene
[106-99-0] (Vol. 71; 1999)
Captafol [2425-06-1]
(Vol. 53; 1991)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Chloramphenicol
[56-75-7] (Vol. 50; 1990)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
a-Chlorinated
toluenes (benzal chloride [98-87-3], benzotrichloride [98-07-7], benzyl
chloride [100-44-7]) and benzoyl chloride [98-88-4] (combined exposures)
(Vol. 29, Suppl. 7,
Vol. 71; 1999)
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
(CCNU) [13010-47-4] (Vol. 26, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
4-Chloro-ortho-toluidine
[95-69-2] (Vol. 77; 2000)
Chlorozotocin
[54749-90-5] (Vol. 50; 1990)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Cisplatin
[15663-27-1] (Vol. 26, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Clonorchis sinensis
(infection with) (Vol. 61; 1994)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Dibenz[a,h]anthracene
[53-70-3] (Vol. 32, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Diethyl sulfate
[64-67-5] (Vol. 54, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Dimethylcarbamoyl
chloride [79-44-7] (Vol. 12, Suppl. 7, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
1,2-Dimethylhydrazine
[540-73-8] (Vol. 4, Suppl. 7, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Dimethyl sulfate
[77-78-1] (Vol. 4, Suppl. 7, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Epichlorohydrin
[106-89-8] (Vol. 11, Suppl. 7, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Ethylene dibromide
[106-93-4] (Vol. 15, Suppl. 7, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
N-Ethyl-N-nitrosourea
[759-73-9] (Vol. 17, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Etoposide
[33419-42-0] (Vol. 76; 2000)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Formaldehyde
[50-00-0] (Vol. 62; 1995)
Glycidol [556-52-5]
(Vol.77; 2000)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Human papillomavirus
type 31 (Vol. 64; 1995)
Human papillomavirus
type 33 (Vol. 64; 1995)
IQ
(2-Amino-3-methylimidazo[4,5-f]quinoline) [76180-96-6] (Vol. 56; 1993)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Kaposi's sarcoma
herpesvirus/human herpesvirus 8 (Vol. 70; 1997)
5-Methoxypsoralen
[484-20-8] (Vol. 40, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
4,4´-Methylene
bis(2-chloroaniline) (MOCA) [101-14-4] (Vol. 57; 1993)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Methyl
methanesulfonate [66-27-3] (Vol. 7, Suppl. 7, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
N-Methyl-N´-nitro-N-nitrosoguanidine
(MNNG) [70-25-7] (Vol. 4, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
N-Methyl-N-nitrosourea
[684-93-5] (Vol. 17, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Nitrogen mustard
[51-75-2] (Vol. 9, Suppl. 7; 1987)
N-Nitrosodiethylamine
[55-18-5] (Vol. 17, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
N-Nitrosodimethylamine
[62-75-9] (Vol. 17, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Phenacetin [62-44-2]
(Vol. 24, Suppl. 7; 1987)
Procarbazine
hydrochloride [366-70-1] (Vol. 26, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 2B to 2A with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Styrene-7,8-oxide
[96-09-3] (Vol. 60; 1994)
Overall Evaluations
of Carcinogenicity to Humans
Group 2B: Possibly carcinogenic to humans
This list contains
all agents, mixtures and exposures evaluated as being in Group 2B. Where
appropriate, chemical abstract numbers are given [in square brackets].
For details of the
evaluation, the relevant Monograph should be consulted (volume number given in
round brackets, followed by year of publication of latest
evaluation). Use a
free-text search to find a particular compound.
Agents
and groups of agents
A-a-C
(2-Amino-9H-pyrido[2,3-b]indole) [26148-68-5] (Vol. 40, Suppl. 7; 1987)
Acetaldehyde
[75-07-0] (Vol. 36, Suppl. 7, Vol. 71; 1999)
Acetamide [60-35-5]
(Vol. 7, Suppl. 7, Vol. 71; 1999)
Acrylonitrile
[107-13-1] (Vol. 71; 1999)
AF-2
[2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide] [3688-53-7] (Vol. 31, Suppl. 7;
1987)
Aflatoxin M1
[6795-23-9] (Vol. 56; 1993)
para-Aminoazobenzene
[60-09-3] (Vol. 8, Suppl. 7; 1987)
ortho-Aminoazotoluene
[97-56-3] (Vol. 8, Suppl. 7; 1987)
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
[712-68-5] (Vol. 7, Suppl. 7; 1987)
Amsacrine
[51264-14-3] (Vol. 76; 2000)
ortho-Anisidine
[90-04-0] (Vol. 73; 1999)
Antimony trioxide
[1309-64-4] (Vol. 47; 1989)
Aramite® [140-57-8]
(Vol. 5, Suppl. 7; 1987)
Auramine [492-80-8]
(technical-grade) (Vol. 1, Suppl. 7; 1987)
Azaserine [115-02-6]
(Vol. 10, Suppl. 7; 1987)
Aziridine [151-56-4]
(Vol. 9, Suppl. 7, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 3 to 2B with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Benzo[b]fluoranthene
[205-99-2] (Vol. 32, Suppl. 7; 1987)
Benzo[j]fluoranthene
[205-82-3] (Vol. 32, Suppl. 7; 1987)
Benzo[k]fluoranthene
[207-08-9] (Vol. 32, Suppl. 7; 1987)
Benzofuran [271-89-6]
(Vol. 63; 1995)
Benzyl violet 4B
[1694-09-3] (Vol. 16, Suppl. 7; 1987)
2,2-Bis(bromomethyl)propane-1,3-diol
[3296-90-0] (Vol. 77; 2000)
Bleomycins
[11056-06-7] (Vol. 26, Suppl. 7; 1987)
(NB: Overall
evaluation upgraded from 3 to 2B with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Bracken fern (Vol.
40, Suppl. 7; 1987)
Bromodichloromethane
[75-27-4] (Vol. 52, Vol. 71; 1999)
Butylated
hydroxyanisole (BHA) [25013-16-5] (Vol. 40, Suppl. 7; 1987)
b-Butyrolactone
[3068-88-0] (Vol. 11, Suppl. 7, Vol. 71; 1999)
Caffeic acid
[331-39-5] (Vol. 56; 1993)
Carbon black
[1333-86-4] (Vol. 65; 1996)
Carbon tetrachloride
[56-23-5] (Vol. 20, Suppl. 7, Vol. 71; 1999)
Catechol [120-80-9]
(Vol. 15, Suppl. 7, Vol. 71; 1999)
Ceramic fibres (Vol.
43; 1988)
Chlordane [57-74-9]
(Vol. 79; 2001)
Chlordecone (Kepone)
[143-50-0] (Vol. 20, Suppl. 7; 1987)
Chlorendic acid
[115-28-6] (Vol. 48; 1990)
para-Chloroaniline
[106-47-8] (Vol. 57; 1993)
Chloroform [67-66-3]
(Vol. 73; 1999)
1-Chloro-2-methylpropene
[513-37-1] (Vol. 63; 1995)
Chlorophenoxy
herbicides (Vol. 41, Suppl. 7; 1987)
4-Chloro-ortho-phenylenediamine
[95-83-0] (Vol. 27, Suppl. 7; 1987)
Chloroprene
[126-99-8] (Vol. 71; 1999)
Chlorothalonil
[1897-45-6] (Vol. 73; 1999)
CI Acid Red 114
[6459-94-5] (Vol. 57; 1993)
CI Basic Red 9
[569-61-9] (Vol. 57; 1993)
CI Direct Blue 15
[2429-74-5] (Vol. 57; 1993)
Citrus Red No. 2 [6358-53-8]
(Vol. 8, Suppl. 7; 1987)
Cobalt [7440-48-4]
and cobalt compounds (Vol. 52; 1991)
(NB: Evaluated as a
group)
para-Cresidine
[120-71-8] (Vol. 27, Suppl. 7; 1987)
Cycasin [14901-08-7]
(Vol. 10, Suppl. 7; 1987)
Dacarbazine
[4342-03-4] (Vol. 26, Suppl. 7; 1987)
Dantron (Chrysazin;
1,8-Dihydroxyanthraquinone) [117-10-2] (Vol. 50; 1990)
Daunomycin
[20830-81-3] (Vol. 10, Suppl. 7; 1987)
DDT [p,p'-DDT,
50-29-3] (Vol. 53; 1991)
N,N'-Diacetylbenzidine
[613-35-4] (Vol. 16, Suppl. 7; 1987)
2,4-Diaminoanisole
[615-05-4] (Vol. 79; 2001)
4,4'-Diaminodiphenyl
ether [101-80-4] (Vol. 29, Suppl. 7; 1987)
2,4-Diaminotoluene
[95-80-7] (Vol. 16, Suppl. 7; 1987)
Dibenz[a,h]acridine
[226-36-8] (Vol. 32, Suppl. 7; 1987)
Dibenz[a,j]acridine
[224-42-0] (Vol. 32, Suppl. 7; 1987)
7H-Dibenzo[c,g]carbazole
[194-59-2] (Vol. 32, Suppl. 7; 1987)
Dibenzo[a,e]pyrene
[192-65-4] (Vol. 32, Suppl. 7; 1987)
Dibenzo[a,h]pyrene
[189-64-0] (Vol. 32, Suppl. 7; 1987)
Dibenzo[a,i]pyrene
[189-55-9] (Vol. 32, Suppl. 7; 1987)
Dibenzo[a,l]pyrene
[191-30-0] (Vol. 32, Suppl. 7; 1987)
1,2-Dibromo-3-chloropropane
[96-12-8] (Vol. 20, Suppl. 7, Vol. 71; 1999)
2,3-Dibromopropan-1-ol
[96-13-9] (Vol. 77; 2000)
para-Dichlorobenzene
[106-46-7] (Vol. 73; 1999)
3,3'-Dichlorobenzidine
[91-94-1] (Vol. 29, Suppl. 7; 1987)
3,3'-Dichloro-4,4'-diaminodiphenyl
ether [28434-86-8] (Vol. 16, Suppl. 7; 1987)
1,2-Dichloroethane
[107-06-2] (Vol. 20, Suppl. 7, Vol. 71; 1999)
Dichloromethane
(methylene chloride) [75-09-2] (Vol. 71; 1999)
1,3-Dichloropropene
[542-75-6] (technical-grade) (Vol. 41, Suppl. 7, Vol. 71; 1999)
Dichlorvos [62-73-7]
(Vol. 53; 1991)
1,2-Diethylhydrazine
[1615-80-1] (Vol. 4, Suppl. 7, Vol. 71; 1999)
Diglycidyl resorcinol
ether [101-90-6] (Vol. 36, Suppl. 7, Vol. 71; 1999)
Dihydrosafrole
[94-58-6] (Vol. 10, Suppl. 7; 1987)
Diisopropyl sulfate
[2973-10-6] (Vol. 54, Vol. 71; 1999)
3,3'-Dimethoxybenzidine
(ortho-Dianisidine) [119-90-4] (Vol. 4, Suppl. 7; 1987)
para-Dimethylaminoazobenzene
[60-11-7] (Vol. 8, Suppl. 7; 1987)
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)-vinyl]-1,3,4-oxadiazole
[25962-77-0]
(Vol. 7, Suppl. 7;
1987)
2,6-Dimethylaniline
(2,6-Xylidine) [87-62-7] (Vol. 57; 1993)
3,3'-Dimethylbenzidine
(ortho-Tolidine) [119-93-7] (Vol. 1, Suppl. 7; 1987)
1,1-Dimethylhydrazine
[57-14-7] (Vol. 4, Suppl. 7, Vol. 71; 1999)
3,7-Dinitrofluoranthene
[105735-71-5] (Vol. 65; 1996)
3,9-Dinitrofluoranthene
[22506-53-2] (Vol. 65; 1996)
1,6-Dinitropyrene
[42397-64-8] (Vol. 46; 1989)
1,8-Dinitropyrene
[42397-65-9] (Vol. 46; 1989)
2,4-Dinitrotoluene
[121-14-2] (Vol. 65; 1996)
2,6-Dinitrotoluene
[606-20-2] (Vol. 65; 1996)
1,4-Dioxane
[123-91-1] (Vol. 11, Suppl. 7, Vol. 71; 1999)
Disperse Blue 1
[2475-45-8] (Vol. 48; 1990)
1,2-Epoxybutane
[106-88-7] (Vol. 47, Vol. 71; 1999)
(NB: Overall
evaluation upgraded from 3 to 2B with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Ethyl acrylate
[140-88-5] (Vol. 39, Suppl. 7, Vol. 71; 1999)
Ethylbenzene
[100-41-4] (Vol. 77; 2000)
Ethyl
methanesulfonate [62-50-0] (Vol. 7, Suppl. 7; 1987)
Foreign bodies,
implanted in tissues (Vol. 74; 1999)
Polymeric, prepared as thin smooth films
(with the exception of poly(glycolic acid))
Metallic, prepared as thin smooth films
Metallic cobalt, metallic nickel and an
alloy powder containing 66-67% nickel, 13-16% chromium and 7% iron
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
[3570-75-0] (Vol. 7, Suppl. 7; 1987)
Furan [110-00-9]
(Vol. 63; 1995)
Glasswool (Vol. 43;
1988)
Glu-P-1
(2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole) [67730-11-4] (Vol. 40,
Suppl. 7; 1987)
Glu-P-2
(2-Aminodipyrido[1,2-a:3',2'-d]imidazole) [67730-10-3] (Vol. 40, Suppl. 7;
1987)
Glycidaldehyde
[765-34-4] (Vol. 11, Suppl. 7, Vol. 71; 1999)
Griseofulvin
[126-07-8] (Vol. 79; 2001)
HC Blue No. 1
[2784-94-3] (Vol. 57; 1993)
Heptachlor [76-44-8]
(Vol. 79; 2001)
Hexachlorobenzene
[118-74-1] (Vol. 79; 2001)
Hexachloroethane
[67-72-1] (Vol. 73; 1999)
Hexachlorocyclohexanes
(Vol. 20, Suppl. 7; 1987)
Hexamethylphosphoramide
[680-31-9] (Vol. 15, Suppl. 7, Vol. 71; 1999)
Human
immunodeficiency virus type 2 (infection with) (Vol. 67; 1996)
Human
papillomaviruses: some types other than 16, 18, 31 and 33 (Vol. 64; 1995)
Hydrazine [302-01-2]
(Vol. 4, Suppl. 7, Vol. 71; 1999)
Indeno[1,2,3-cd]pyrene
[193-39-5] (Vol. 32, Suppl. 7; 1987)
Iron-dextran complex
[9004-66-4] (Vol. 2, Suppl. 7; 1987)
Isoprene [78-79-5]
(Vol. 60, Vol. 71; 1999)
Lasiocarpine
[303-34-4] (Vol. 10, Suppl. 7; 1987)
Lead [7439-92-1] and
lead compounds, inorganic (Vol. 23, Suppl. 7; 1987)
(NB: Evaluated as a
group)
Magenta [632-99-5]
(containing CI Basic Red 9) (Vol. 57; 1993)
Magnetic fields
(extremely low-frequency) (Vol. 80; 2002)
MeA-a-C
(2-Amino-3-methyl-9H-pyrido[2,3-b]indole) [68006-83-7] (Vol. 40, Suppl. 7;
1987)
Medroxyprogesterone
acetate [71-58-9] (Vol. 21, Suppl. 7; 1987)
MeIQ
(2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) [77094-11-2] (Vol. 56; 1993)
MeIQx
(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) [77500-04-0] (Vol. 56; 1993)
Merphalan [531-76-0]
(Vol. 9, Suppl. 7; 1987)
2-Methylaziridine
(Propyleneimine) [75-55-8] (Vol. 9, Suppl. 7, Vol. 71; 1999)
Methylazoxymethanol
acetate [592-62-1] (Vol. 10, Suppl. 7; 1987)
5-Methylchrysene
[3697-24-3] (Vol. 32, Suppl. 7; 1987)
4,4'-Methylene
bis(2-methylaniline) [838-88-0] (Vol. 4, Suppl. 7; 1987)
4,4'-Methylenedianiline
[101-77-9] (Vol. 39, Suppl. 7; 1987)
Methylmercury compounds
(Vol. 58; 1993)
(NB: Evaluated as a
group)
2-Methyl-1-nitroanthraquinone
[129-15-7] (uncertain purity) (Vol. 27, Suppl. 7; 1987)
N-Methyl-N-nitrosourethane
[615-53-2] (Vol. 4, Suppl. 7; 1987)
Methylthiouracil
[56-04-2] (Vol. 79; 2001)
Metronidazole
[443-48-1] (Vol. 13, Suppl. 7; 1987)
Mirex [2385-85-5]
(Vol. 20, Suppl. 7; 1987)
Mitomycin C [50-07-7]
(Vol. 10, Suppl. 7; 1987)
Mitoxantrone
[65271-80-9] (Vol. 76; 2000)
Monocrotaline
[315-22-0] (Vol. 10, Suppl. 7; 1987)
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone
[3795-88-8] (Vol. 7, Suppl. 7; 1987)
Nafenopin [3771-19-5]
(Vol. 24, Suppl. 7; 1987)
Nickel, metallic
[7440-02-0] and alloys (Vol. 49; 1990)
Niridazole [61-57-4]
(Vol. 13, Suppl. 7; 1987)
Nitrilotriacetic acid
[139-13-9] and its salts (Vol. 73; 1999)
(NB: Evaluated as a
group)
5-Nitroacenaphthene
[602-87-9] (Vol. 16, Suppl. 7; 1987)
2-Nitroanisole
[91-23-6] (Vol. 65; 1996)
Nitrobenzene
[98-95-3] (Vol. 65; 1996)
6-Nitrochrysene
[7496-02-8] (Vol. 46; 1989)
Nitrofen [1836-75-5]
(technical-grade) (Vol. 30, Suppl. 7; 1987)
2-Nitrofluorene
[607-57-8] (Vol. 46; 1989)
1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone
[555-84-0] (Vol. 7, Suppl. 7; 1987)
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide
[531-82-8] (Vol. 7, Suppl. 7; 1987)
Nitrogen mustard
N-oxide [126-85-2] (Vol. 9, Suppl. 7; 1987)
Nitromethane
[75-52-5] (Vol. 77; 2000)
2-Nitropropane
[79-46-9] (Vol. 29, Suppl. 7, Vol. 71; 1999)
1-Nitropyrene
[5522-43-0] (Vol. 46; 1989)
4-Nitropyrene
[57835-92-4] (Vol. 46; 1989)
N-Nitrosodi-n-butylamine
[924-16-3] (Vol. 17, Suppl. 7; 1987)
N-Nitrosodiethanolamine
[1116-54-7] (Vol. 17, Suppl. 7, Vol. 77; 2000)
N-Nitrosodi-n-propylamine
[621-64-7] (Vol. 17, Suppl. 7; 1987)
3-(N-Nitrosomethylamino)propionitrile
[60153-49-3] (Vol. 37, Suppl. 7; 1987)
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) [64091-91-4] (Vol. 37, Suppl. 7; 1987)
N-Nitrosomethylethylamine
[10595-95-6] (Vol. 17, Suppl. 7; 1987)
N-Nitrosomethylvinylamine
[4549-40-0] (Vol. 17, Suppl. 7; 1987)
N-Nitrosomorpholine
[59-89-2] (Vol. 17, Suppl. 7; 1987)
N'-Nitrosonornicotine
[16543-55-8] (Vol. 37, Suppl. 7; 1987)
N-Nitrosopiperidine
[100-75-4] (Vol. 17, Suppl. 7; 1987)
N-Nitrosopyrrolidine
[930-55-2] (Vol. 17, Suppl. 7; 1987)
N-Nitrososarcosine
[13256-22-9] (Vol. 17, Suppl. 7; 1987)
Ochratoxin A
[303-47-9] (Vol. 56; 1993)
Oestrogen-progestogen
therapy, postmenopausal (Vol. 72; 1999)
Oil Orange SS
[2646-17-5] (Vol. 8, Suppl. 7; 1987)
Oxazepam [604-75-1]
(Vol. 66; 1996)
Palygorskite
(attapulgite) [12174-11-7] (long fibres, > 5 micrometers) (Vol. 68; 1997)
Panfuran S [794-93-4]
(containing dihydroxymethylfuratrizine)
(Vol. 24, Suppl. 7;
1987)
Phenazopyridine
hydrochloride [136-40-3] (Vol. 24, Suppl. 7; 1987)
Phenobarbital
[50-06-6] (Vol. 79; 2001)
Phenolphthalein
[77-09-8] (Vol. 76; 2000)
Phenoxybenzamine
hydrochloride [63-92-3] (Vol. 24, Suppl. 7; 1987)
Phenyl glycidyl ether
[122-60-1] (Vol. 47, Vol. 71; 1999)
Phenytoin [57-41-0]
(Vol. 66; 1996)
PhIP
(2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) [105650-23-5] (Vol. 56; 1993)
Polychlorophenols and
their sodium salts (mixed exposures) (Vol. 41, Suppl. 7, Vol. 53, Vol. 71;
1999)
Ponceau MX
[3761-53-3] (Vol. 8, Suppl. 7; 1987)
Ponceau 3R
[3564-09-8] (Vol. 8, Suppl. 7; 1987)
Potassium bromate
[7758-01-2] (Vol. 73; 1999)
Progestins (Suppl. 7;
1987)
Progestogen-only
contraceptives (Vol. 72; 1999)
1,3-Propane sultone
[1120-71-4] (Vol. 4, Suppl. 7, Vol. 71; 1999)
b-Propiolactone
[57-57-8] (Vol. 4, Suppl. 7, Vol. 71; 1999)
Propylene oxide
[75-56-9] (Vol. 60; 1994)
Propylthiouracil
[51-52-5] (Vol. 79; 2001)
Rockwool (Vol. 43;
1988)
Safrole [94-59-7]
(Vol. 10, Suppl. 7; 1987)
Schistosoma japonicum
(infection with) (Vol. 61; 1994)
Slagwool (Vol. 43;
1988)
Sodium
ortho-phenylphenate [132-27-4] (Vol. 73; 1999)
Sterigmatocystin
[10048-13-2] (Vol. 10, Suppl. 7; 1987)
Streptozotocin
[18883-66-4] (Vol. 17, Suppl. 7; 1987)
Styrene [100-42-5]
(Vol. 60; 1994)
(NB: Overall
evaluation upgraded from 3 to 2B with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Sulfallate [95-06-7]
(Vol. 30, Suppl. 7; 1987)
Tetrafluoroethylene
[116-14-3] (Vol. 19, Suppl. 7, Vol. 71; 1999)
Tetranitromethane
[509-14-8] (Vol. 65; 1996)
Thioacetamide
[62-55-5] (Vol. 7, Suppl. 7; 1987)
4,4'-Thiodianiline
[139-65-1] (Vol. 27, Suppl. 7; 1987)
Thiouracil [141-90-2]
(Vol. 79; 2001)
Toluene diisocyanates
[26471-62-5] (Vol. 39, Suppl. 7, Vol. 71; 1999)
Toxins derived from
Fusarium moniliforme (Vol. 56; 1993)
Trichlormethine
(Trimustine hydrochloride) [817-09-4] (Vol. 50; 1990)
Trp-P-1
(3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole) [62450-06-0] (Vol. 31, Suppl. 7;
1987)
Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole)
[62450-07-1] (Vol. 31, Suppl. 7; 1987)
Trypan blue [72-57-1]
(Vol. 8, Suppl. 7; 1987)
Uracil mustard
[66-75-1] (Vol. 9, Suppl. 7; 1987)
Urethane [51-79-6]
(Vol. 7, Suppl. 7; 1987)
Vinyl acetate
[108-05-4] (Vol. 63; 1995)
4-Vinylcyclohexene
[100-40-3] (Vol. 60; 1994)
4-Vinylcyclohexene
diepoxide [106-87-6] (Vol. 60; 1994)
Zalcitabine
[7481-89-2] (Vol. 76; 2000)
Zidovudine (AZT)
[30516-87-1] (Vol. 76; 2000)
Mixtures
Bitumens [8052-42-4],
extracts of steam-refined and air-refined (Vol. 35, Suppl. 7; 1987)
Carrageenan
[9000-07-1], degraded (Vol. 31, Suppl. 7; 1987)
Chlorinated paraffins
of average carbon chain length C12 and average degree of chlorination
approximately 60% (Vol. 48; 1990)
Coffee (urinary
bladder) (Vol. 51; 1991)
(NB: There is some
evidence of an inverse relationship between coffee drinking and cancer of the
large bowel; coffee drinking could not be classified as to its
carcinogenicity to
other organs)
Diesel fuel, marine
(Vol. 45; 1989)
(NB: Overall
evaluation upgraded from 3 to 2B with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Engine exhaust,
gasoline (Vol. 46; 1989)
Fuel oils, residual
(heavy) (Vol. 45; 1989)
Gasoline (Vol. 45;
1989)
(NB: Overall
evaluation upgraded from 3 to 2B with supporting evidence from other data
relevant to the evaluation of carcinogenicity and its mechanisms)
Pickled vegetables
(traditional in Asia) (Vol. 56; 1993)
Polybrominated
biphenyls [Firemaster BP-6, 59536-65-1] (Vol. 41, Suppl. 7; 1987)
Toxaphene
(Polychlorinated camphenes) [8001-35-2] (Vol. 79; 2001)
Welding fumes (Vol.
49; 1990)
Exposure
circumstances
Carpentry and joinery
(Vol. 25, Suppl. 7; 1987)
Dry cleaning (occupational
exposures in) (Vol. 63; 1995)
Printing processes
(occupational exposures in) (Vol. 65; 1996)
Textile manufacturing
industry (work in) (Vol. 48; 1990)
Last updated: 8 March
2002
Michigan Occupational Safety and Health Rule 2301
and
Group 1 Human
Carcinogens (EPA)
http://www.iarc.fr/monoeval/crthgr1.htm
The following
chemicals are included in the Michigan Occupational Safety and Health Rule
2301:
Vinyl Chloride
Methylenedianaline
Ethylene Oxide
Formaldehyde
Acrylonitrile
Inorganic Arsenic
Cadmium
Lead
Benzene
New Employee Chemical
Hygiene Orientation and Training Checklist
Name________________________________S.S. #____________________
Position______________________________Supervisor_________________
1.
By Chemical Hygiene Officer
Right-to-Know Law
Laboratory Specific Standard Operating Procedures
Chemical Procurement, Storage, Handling
PPE
Labeling
Waste Handling
Housekeeping
Engineering Controls
Permit System
Emergency Action Plan
Training Completed by______________________Date___________
Employee Signature________________________Date___________
(Signature acknowledges that the above topics have
been adequately communicated)
2.
By Laboratory Supervisor
Introduction
to operations where chemical and physical hazards are present/types of hazards
encountered.
Required work practices
PPE
Emergency procedures
Detection of chemical hazards
Location and training on SOP(s), MSDS(s), and CHP
Labeling system
Training Completed
by______________________Date___________
For Building/Room Number_________________________________
Training Completed by______________________Date___________
For Building/Room Number_________________________________
Employee Signature________________________Date___________
(Signature acknowledges that the above topics have
been adequately communicated)
3.
Review and Testing (by Chemical Hygiene Officer)
Review
work practices and procedures
Answer employee questions
Test
Review and Testing Completed by______________________Date_________
Employee Signature_________________________________Date_________
Laboratory Operations Permit
Date:
Name of Employee Requesting Permit:
Work Area where Permitted Operation will Ocurr:
Name of Supervisor for the Work Area:
Names of Employee to
be Included in Permitted Operation:
Time Period for which
the Requested Permit will be Issued for:
Summary of Reason for
Requesting Permit:
Attach a complete
description of all activities that will be occurring in the laboratory during
the time period of these proposed permitted activities, including those that
the permit will cover.
Submit completed form
to the Chemical Hygiene Officer.
3.2
Children at MTU
Policy: It is the policy of Michigan Technological University that children under the age of 12 are not permitted in work areas (e.g., offices, classrooms, shops), except those spaces specifically intended for public use, without the written permission of the department chair or director. Children under the age of 12 who are not enrolled in a Michigan Tech class or program are not permitted in laboratories at any time. Children under the age of 16 must be under the direct supervision of the laboratory supervisor while visiting or participating in MTU sponsored activities in laboratories containing hazardous chemicals or equipment.
Additional Information: It is the intent of this policy that the department chair or director will verify that a student or employee has a workable plan to provide age-appropriate supervision and protection from foreseeable safety and health hazards before allowing a child to be brought into a campus work area. Children must not be allowed to roam the building unsupervised. Permission may not be given for a child under 12 to enter a laboratory or other area with hazardous substances, machinery or tools except as part of an organized event where special provisions have been made to prevent exposure to these hazards.